Browse the evidence

Physical activity and exercise training modify the biological effects of accelerated aging considerably.

Incorporating regular physical activity and exercise can significantly mitigate the effects of aging on cardiovascular health.

All-cause mortality rate was 30% lower per SD greater METs (hazard ratio (HR) = 0.70; rate difference (RD), -2.71 deaths/1000 person-years).

Improving cardiorespiratory fitness can significantly lower mortality risk in individuals with type 2 diabetes.

An SD greater METs predicted lower cardiovascular disease mortality (HR, 0.45; RD, -1.65 cases/1000 person-years).

Increasing cardiorespiratory fitness can reduce the risk of cardiovascular disease mortality in individuals with type 2 diabetes.

Greater CRF is associated with reduced risks of mortality and cardiovascular disease events.

Enhancing cardiorespiratory fitness is crucial for lowering mortality and cardiovascular disease risks in this population.

Some patients with type 2 diabetes can experience sustained metabolic improvement to near-normal levels of glycemia, recognized as remission of diabetes.

Practitioners should recognize the potential for remission in T2DM patients.

Obesity increases stress throughout the musculoskeletal system and carries a higher risk for the development of osteoarthritis and various other musculoskeletal conditions.

Healthcare providers should consider the musculoskeletal risks associated with obesity when treating patients.

Obesity is associated with increased risk of complications in patients undergoing total joint arthroplasty.

Surgeons should be aware of the increased risks when treating obese patients in joint surgeries.

The deuterated water method allows for the assessment of muscle tissue protein synthesis rates under free-living conditions.

This method can be used to measure protein synthesis in everyday life, enhancing research relevance.

The use of anti-obesity medications in patients with heart failure may improve functional status, biomarkers of inflammation, and heart failure stability.

Anti-obesity medications may not only aid in weight loss but also enhance overall heart failure management.

MyoPS rates were comparable between resistance-only exercise and concurrent exercise groups before and after training.

Both resistance-only and concurrent exercise can effectively promote muscle protein synthesis in moderately active individuals.

Concurrent exercise did not compromise the anabolic response to resistance-only exercise, before or after training.

Practitioners can incorporate concurrent exercise without fear of diminishing the benefits of resistance training.

The gas-filled IGB had fewer serious adverse events and better tolerability than the fluid-filled IGB.

The gas-filled IGB may be a safer option for patients.

Patients exhibited initial physical functioning scores below the reference values yet demonstrated substantial physical recuperation by the 12-week mark following their ICU discharge in both groups.

Nutrition interventions may play a crucial role in recovery for post-ICU patients.

Moderate-quality evidence revealed beneficial relationships between the intake of omega-6 fatty acids and cardiovascular disease (CVD) mortality, overall cancer mortality, and all-cause mortality.

Increasing omega-6 fatty acid intake may reduce risks of CVD and cancer.

Moderate-quality evidence suggested that seafood-derived omega-3 fatty acids were associated with reduced triglyceride levels, elevated high density lipoprotein cholesterol, and a decreased risk of coronary heart disease.

Encouraging seafood consumption may improve heart health and lipid profiles.

Several anti-obesity drugs show significant reduction of fat mass, particularly visceral fat.

Practitioners can consider these drugs for effective fat loss, especially visceral fat.

Tirzepatide is associated with a reduction in systolic arterial pressure by 4 to 6 mmHg and total cholesterol by 4–6% compared to baseline.

TZP may provide cardiovascular benefits in addition to glycemic control.

Myofibrillar protein synthesis rates did not differ between omnivorous and vegan dietary patterns.

Both omnivorous and vegan diets can support similar rates of muscle protein synthesis during resistance training.

Obesity and insulin resistance are associated with compromised muscle proteostasis.

Understanding the impact of obesity on muscle health can guide interventions.

HIIT tends to benefit proteostasis by increasing muscle protein turnover rates.

HIIT may be a beneficial strategy for enhancing muscle health in obese individuals.

Satellite cell activation was similar between groups in the untrained state but showed a trend toward greater increases with MIS after RET.

There may be potential benefits of multi-ingredient supplementation on satellite cell activation post-exercise.

The intake of saturated fatty acids (SAFAs) is directly associated with coronary heart disease (CHD) mortality, with a hazard ratio of 1.28 for one standard deviation increase.

Practitioners should consider the impact of saturated fat intake on heart disease risk in middle-aged men.

The intake of mono-unsaturated fatty acids (MUFAs) is inversely associated with coronary heart disease (CHD) mortality, with a hazard ratio of 0.84 for one standard deviation increase.

Practitioners should encourage the intake of mono-unsaturated fats to potentially lower heart disease risk.

Tirzepatide is linked to a significantly reduced risk of overall hematologic malignancy (OR = 0.14, 95%CI = 0.03-0.60), particularly for lymphoma.

Tirzepatide may be a safer option for patients concerned about hematologic malignancies.