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Greater weight loss achieved at month-6 was the main predictor associated with success in weight loss (> 5%) over 2 years.

Encouraging significant weight loss in the initial months may enhance long-term weight loss success.

Increased physical activity was the most consistent positive correlate of weight loss maintenance.

Practitioners should emphasize the importance of physical activity in weight loss maintenance strategies.

The review identified 51 weight loss and maintenance strategies grouped in 14 domains.

Practitioners can utilize these identified strategies to enhance weight loss maintenance programs.

Patients in the POWeR+F group achieved an additional weight reduction of 1.5 kg averaged over 12 months compared to the control group.

Incorporating brief nurse support with web-based interventions can enhance weight loss outcomes in obese patients.

Patients in the POWeR+R group achieved an additional weight reduction of 1.3 kg averaged over 12 months compared to the control group.

Remote nurse support combined with web-based interventions can also lead to significant weight loss in obese patients.

32% of patients in the POWeR+R group maintained a clinically important 5% weight reduction at month 12.

A web-based behavioral program with brief remote follow-up can help a significant proportion of obese patients maintain weight loss.

In males only, SPA correlated inversely to the rate of subsequent body weight change (r = -0.25, P less than 0.05) and the rate of fat-mass change (r = -0.35, P less than 0.005).

Encouraging higher SPA may help in managing body weight and fat mass in males.

Fish with higher amounts of ω-3 fatty acids are associated with a lower risk of CVD.

Encouraging the consumption of oily fish rich in ω-3 fatty acids may be beneficial for patients at risk of CVD.

Substitution of low- and no-calorie sweetened beverages (LNCSBs) for sugar-sweetened beverages (SSBs) was associated with a reduction in body weight by 1.06 kg.

Practitioners may consider recommending LNCSBs as a substitute for SSBs to aid in weight management.

Substitution of LNCSBs for SSBs was associated with a reduction in body mass index (BMI) by 0.32.

Practitioners may use LNCSBs to help reduce BMI in at-risk populations.

Feeding frequency was positively associated with reductions in fat mass and body fat percentage as well as an increase in fat-free mass.

Increasing meal frequency may help in reducing fat mass and increasing lean mass.

Participants with OSA and type 2 diabetes mellitus receiving intensive lifestyle intervention (ILI) for weight loss had reduced OSA severity at 10 years.

Practitioners should consider ILI as an effective long-term strategy for managing OSA severity in patients with type 2 diabetes.

OSA remission at 10 years was more common with ILI (34.4%) than DSE (22.2%).

ILI may be a more effective approach for achieving OSA remission in this population.

Guidelines on dietary sugar recommend a decrease in the consumption of foods containing nonintrinsic sugars.

Health professionals should consider these guidelines when advising on sugar intake.

After 2 years, lifestyle interventions can facilitate weight loss that equates to ~5%.

Practitioners can expect approximately 5% weight loss from lifestyle interventions over two years.

A multifactorial maintenance program is imperative to mitigate weight regain.

Implementing a comprehensive maintenance program is crucial for long-term weight management.

Nutritionally inadequate dietary intake is a leading contributor to chronic cardiometabolic diseases.

Practitioners should focus on improving dietary intake to prevent chronic diseases.

Protein needs for energy-restricted resistance-trained athletes are likely 2.3-3.1g/kg of FFM scaled upwards with severity of caloric restriction and leanness.

Athletes in caloric restriction should consider higher protein intakes to maintain muscle mass.

Body fat percentage decreased (0.5-6.6%) in all study groups.

Resistance-trained athletes can expect reductions in body fat when in caloric deficit.

Higher meal frequency and regular eating patterns are more advantageous for energy balance than irregular and infrequent meals.

Encouraging regular meal patterns may aid in weight management strategies.

The adequate dietary protein intake for individuals over the age of 19 is approximately 0.8-0.9 g protein per kg of body weight per day.

Practitioners should recommend a protein intake of 0.8-0.9 g/kg for healthy adults.

Bariatric surgery results in a mean weight loss of −22.68 kg compared to GLP-1 receptor agonists.

Bariatric surgery may be more effective than GLP-1 receptor agonists for significant weight loss.

Among meta-analyses, 4/5 with critically low quality showed low-carbohydrate diet superiority for weight loss (0.7-4.0 kg).

Low-carbohydrate diets may lead to significant weight loss, but caution is needed due to the quality of the evidence.

Individualized lifestyle interventions reduced the mean difference in BMI by -0.63 kg/m2 compared to control groups.

Practitioners can consider individualized lifestyle interventions as a method for weight management in SMI patients.