Browse the evidence

There may be a potential causal relationship between tirzepatide and vitreous hemorrhage in nondiabetic patients.

Caution is advised when prescribing tirzepatide, especially in nondiabetic patients.

A better healthcare provision for obesity treatment will initially burden the healthcare system but is expected to lead to a reduction in the obesity epidemic and cost savings in the long term.

Practitioners should prepare for initial challenges in the healthcare system while advocating for long-term benefits.

A broad societal consensus is crucial for implementing measures to reduce obesogenic living conditions.

Practitioners should engage with community efforts to create healthier environments.

Emerging clinical trials support the potential of GLP-1 receptor agonists in reversing cancer risk.

Practitioners should stay updated on clinical trial results regarding GLP-1 agonists and cancer risk.

Dietary supplements are generally safe, but their regulation is less stringent than for medicines.

Practitioners should ensure patients are aware of the regulatory status of dietary supplements.

A 10% energy surplus did not result in a significant change in body protein mass (0.00 kg; 95% CI, -0.38-0.39 kg; P = 0.980).

A modest increase in energy intake may not be sufficient to promote body protein mass gain.

Protein supplementation does not seem to provide further improvements in untrained and healthy subjects.

Practitioners should consider the training status of individuals when recommending protein supplementation.

The prevalence of any remission in the plate model was 27.1% during the first 2 years, decreasing over time.

The plate model may initially improve diabetes remission rates, but these rates decline over time.

Elevated LDL-cholesterol reflects an imbalance in food energy intake and expenditure.

Practitioners should consider energy balance when addressing LDL-cholesterol levels.

Counselors spent less time providing feedback on participant self-monitoring data over the course of the study, decreasing from a mean of 53 minutes to 26 minutes.

Counselors can improve efficiency in providing feedback over time, which may reduce costs in technology-based weight loss interventions.

Counselors may be increasing their efficiency in providing feedback over time.

Counselors should focus on developing skills that enhance feedback efficiency over time.

People in Northern China often consume more plant-based foods.

Understanding local dietary habits can inform nutritional guidance and interventions.

The study will carry out meta-regression to determine the influence of moderator variables on findings.

Understanding moderator variables can help tailor training programs more effectively.

At the lowest income level, the proportions of individuals in the best carbohydrate quality category reduced from 26.9% to 20.6%.

Practitioners should be aware that lower income is associated with reduced dietary quality in carbohydrates.

At the highest income level, the proportions of individuals in the best carbohydrate quality category increased from 22.9% to 26.6%.

Practitioners should recognize that higher income is associated with improved dietary quality in carbohydrates.

No significant differences were observed between the 4-6 RPE and 7-9 RPE groups for relative intensity or relative volume.

Training intensity and volume were similar between the two RPE groups, suggesting flexibility in training approaches.

No significant group × time interactions were observed between the two training protocols.

Both training approaches yield similar results, allowing flexibility in training intensity without compromising strength gains.

Trivial between-group effect sizes were observed when comparing the strength gains of the 4-6 RPE group to the 7-9 RPE group (g = -0.12).

The similarity in strength gains suggests that both training intensities may be equally effective for improving squat strength.

The findings regarding back squat strength improvements between resistance training with 4-6 RPE and 7-9 RPE are statistically inconclusive.

Further research may be needed to clarify the effectiveness of different RPE levels in resistance training.

Meals in the bottom versus top half of glycemic responses ranked by Abbott resulted in 50±10% less glycemic reduction compared to Dexcom.

Meal planning should account for differences in CGM readings to optimize glycemic control.

Mathematical models can infer physiological variables that are difficult to measure directly.

Practitioners can leverage mathematical models to gain insights into physiological variables that are otherwise challenging to assess.

The discrepancy in energy expenditure between the metabolic ward and respiratory chamber was smaller than previously found in exercising men.

This suggests that exercise may significantly influence energy expenditure measurements.

Failure to reproduce previous results may be due to the lack of exercise, inclusion of women, or wider range of BMIs.

Understanding these factors can help in designing future studies on energy expenditure.

The historical view that 'a calorie is a calorie' is an oversimplification.

Practitioners should be cautious of oversimplified views on calorie intake.