Browse the evidence

Lebensstilinterventionen sind essenziell, während medikamentöse und operative Ansätze Potenzial zur Reduktion kardiovaskulärer Ereignisse zeigen.

Practitioners should implement lifestyle changes while considering pharmacological and surgical options for patients.

GLP-1 receptor agonists reduce central adiposity, SBP, DBP, and insulin resistance.

Practitioners should consider GLP-1 receptor agonists for improving metabolic health in this population.

Insulin resistance leads to a metabolic profile that is strongly atherogenic, accelerating atherosclerosis and cardiovascular diseases.

Understanding the atherogenic effects of insulin resistance can guide cardiovascular risk management.

Clamp-derived insulin sensitivity increased by 50% in adults with obesity and type 2 diabetes, and HOMA-IR decreased by 26% in both studies.

Improvements in insulin sensitivity are achievable through lifestyle interventions, regardless of body composition changes.

Increasing fat availability leads to higher rates of whole-body and muscular lipid use during regular moderate-intensity aerobic activity.

Practitioners can utilize fat availability strategies to enhance lipid utilization during aerobic activities.

Significantly fewer participants in the bariatric surgery group required TKA following weight loss.

Practitioners should note that bariatric surgery may lead to symptom improvement, reducing the need for TKA.

Chronic low-grade metabolic acidosis can have detrimental effects on systemic health, physical performance, and inflammation.

Athletes should be aware that chronic low-grade metabolic acidosis can negatively impact their health and performance.

Metabolic health, rather than obesity, is a key predictor of adverse events in chronic coronary syndrome (CCS) prevention.

Practitioners should prioritize assessing metabolic health over BMI in cardiovascular risk evaluations.

MetFlex to fat displayed satisfactory test-retest reliability (intraclass correlation coefficient > 0.70) for several outcomes.

This method can reliably assess metabolic flexibility to high-fat meals in healthy individuals.

Overnight changes in substrate oxidation following a high-fat dinner meal represent a unique aspect of MetFlex.

Practitioners should consider overnight metabolic responses when assessing dietary impacts.

Postprandial plasma lipids and lipoproteins were examined after a 2-week low-carbohydrate diet compared to a 2-week low-fat diet.

This study provides insights into how different dietary approaches may affect lipid and lipoprotein levels post-meal.

Die Gewichtsentwicklung in den ersten Wochen bis Monaten nach Initialisierung einer Therapie ist der stärkste Prädiktor für Gewichtszunahme assoziiert mit AP und AD.

Monitoring weight in the early stages of treatment can help predict long-term weight gain.

The effectiveness of ESG is influenced by the patient's body mass index (BMI), being more effective in those with lower BMIs.

Practitioners should assess BMI when recommending ESG to optimize treatment outcomes.

Sleeve gastrectomy can result in weight loss up to 23% at 1 year and is associated with a lower risk of malabsorption compared to Roux-en-Y gastric bypass.

Surgeons and healthcare providers should consider sleeve gastrectomy as a viable option for weight loss in transplant candidates.

Die Gewichtsentwicklung in den ersten Wochen bis Monaten nach Initialisierung einer Therapie ist der stärkste Prädiktor für Gewichtszunahme assoziiert mit AP und AD.

Monitoring weight in the early stages of treatment can help predict long-term outcomes.

The Open Formulary group had a modest weight reduction of −2.5 kg ± 4.4 kg.

Practitioners may note that an open formulary can also contribute to modest weight loss in patients.

Obesity predicts cardiovascular disease mortality.

Practitioners should consider obesity as a significant risk factor for cardiovascular disease mortality.

Higher BMIs are associated with the development of chronic kidney disease.

Weight management may be crucial for preventing chronic kidney disease.

The removal of amino acids during hemodialysis contributes substantially to protein malnutrition in patients.

Practitioners should ensure adequate protein intake for patients undergoing hemodialysis.

Lower HbA1c is associated with 0.17 to 0.22 standard deviation better cognitive function across all domains.

Improving diabetes control to achieve lower HbA1c levels may enhance cognitive function in individuals with type 2 diabetes.

There were no significant differences in changes in waist circumference, BMI, body fat, or metabolic risk factors between the two groups.

Practitioners may consider that time-restricted eating does not provide additional metabolic benefits compared to daily calorie restriction.

Psychotropic drug-related weight gain (PDWG) is highly associated with non-initiation, discontinuation, and dissatisfaction with psychiatric drugs.

Practitioners should be aware of the impact of PDWG on patient adherence to psychiatric medications.

Tirzepatide improved glucose control in overweight and obese patients with type 1 diabetes.

Tirzepatide may be beneficial for improving glycemic control in this demographic.

Higher variability of body mass index (BMI) is associated with a significantly increased risk of all-cause mortality, cardiovascular deaths, and cardiovascular events in individuals with type 2 diabetes in the control group.

Practitioners should monitor BMI variability in patients with type 2 diabetes as it may indicate higher risks for adverse cardiovascular outcomes.