Browse the evidence

Population aging and growth alone will increase annual cardiovascular disease events by approximately 50% between 2010 and 2030 in China, even if all risk factors remain constant at 2000 levels.

Even with perfect health behaviors, the aging of the Chinese population will drive a 50% increase in cardiovascular events by 2030, necessitating proactive public health interventions.

For heart failure treatment, diuretics are more effective than exercise interventions in reducing mortality.

If you have heart failure, taking prescribed diuretics is more effective than exercise for preventing death. However, exercise is still safe and recommended as part of your overall care plan, as it does not appear to cause harm and may improve functional capacity.

Pharmacological clearance of senescent cells using senolytics (specifically dasatinib and quercetin) extends health span and reduces age-related pathologies in mouse models.

This paper describes a preclinical strategy using specific drugs (senolytics) to clear aged cells. It is not a DIY protocol. The findings suggest that targeting cellular aging mechanisms is a viable path for extending health span, but human application requires further clinical trials to establish safety and efficacy.

Genetic ablation of senescent cells using the INK-ATTAC transgenic system delays age-related phenotypes and extends lifespan in mice.

This is a foundational scientific finding showing that removing senescent cells can extend life in mice. It provides the biological rationale for developing drugs (senolytics) to do the same in humans, but the genetic method itself is not a human intervention.

Constitutive responses to stress and DNA damage, including upregulation of heat shock proteins and proteases, are observed with age in Drosophila and worms, representing a conserved transcriptomic response to cellular damage.

In flies and worms, aging is associated with an upregulation of stress response genes like heat shock proteins. This suggests an attempt by the cell to cope with accumulated damage, although this pattern is less clear in mammals.

High-salt diets can enhance antitumor immunity in melanoma and lung cancer by promoting the differentiation of M1-like macrophages and increasing the infiltration and function of CD8+ T cells.

For patients with melanoma or lung cancer, high-salt intake might boost immune response, but this is a complex trade-off. Do not increase salt intake without consulting your oncologist, as it may not be suitable for everyone, especially those with heart conditions.