Browse the evidence

RT performed to set failure likely exacerbates neuromuscular fatigue, muscle damage, and perceived discomfort compared to non-failure RT.

Practitioners should be cautious of the increased fatigue and discomfort associated with set failure training.

Weight loss correlated with significant decreases in leptin and favorable modulation of inflammatory cytokines and lipid profiles.

Weight loss may improve metabolic health markers in breast cancer survivors.

Processing can be used to modify food properties to help reduce overconsumption.

Practitioners can explore food processing techniques to create healthier options.

Regular physical activity boosts host immunity and facilitates a more diverse gut microbiome.

Encouraging regular physical activity can enhance immune function and gut health.

Nonelderly males with overweight and obesity experience a reduction in skeletal muscle mass of about 2 to 2.5 kg per 10-kg weight loss during voluntary caloric restriction.

Practitioners should be aware that caloric restriction can lead to significant muscle loss in males, which may need to be addressed in weight loss programs.

Nonelderly females with overweight and obesity experience a reduction in skeletal muscle mass of about 1 to 1.5 kg per 10-kg weight loss during voluntary caloric restriction.

Practitioners should be aware that caloric restriction can lead to significant muscle loss in females, which may need to be addressed in weight loss programs.

Model predictions of relative skeletal muscle changes with caloric restriction were validated in longitudinal studies.

The validation of these models can help practitioners predict muscle loss during caloric restriction more accurately.

Patients treated with semaglutide 2.4 mg had lower rates of all-cause death compared to placebo (HR: 0.81; 95% CI: 0.71-0.93).

Semaglutide may be an effective treatment for reducing overall mortality in patients with cardiovascular disease.

The study suggests reassessing the preoperative withholding guidelines for GLP-1 receptor agonists.

Healthcare providers may need to update their protocols regarding GLP-1 RA use before surgery.

Tirzepatide provides better value for money than semaglutide for weight reduction.

Healthcare providers may prefer prescribing tirzepatide over semaglutide for weight management.

Tirzepatide, a dual GLP-1/GIP receptor agonist, significantly reduces Obstructive Sleep Apnea severity (AHI) and improves cardiometabolic biomarkers in patients with moderate-to-severe OSA and obesity, leading to FDA approval for this indication.

If you have moderate-to-severe sleep apnea and obesity, ask your doctor about tirzepatide. It is an FDA-approved treatment that reduces breathing interruptions during sleep and improves heart health markers. It requires weekly injections and lifestyle counseling, but offers a viable alternative or adjunct to CPAP for those struggling with adherence or residual symptoms.

Patients treated with GLP-1 RAs experienced a lower occurrence of sight-threatening complications, including blindness (HR, 0.77; 95% CI, 0.73-0.82).

GLP-1 RAs may help reduce the risk of severe ocular complications in T2D patients.

Lifestyle measures and various drugs can reduce CVD risk in T2DM patients.

Implementing lifestyle changes and appropriate medications can help manage cardiovascular risk in T2DM patients.

Biomechanical, anthropometric, experiential, and sex predictors show stronger relationships with squat 1RM compared to psychological variables.

Emphasize physical training and assessment over psychological factors for improving squat performance.

Back squat strength in a heterogeneous population is multifactorial and more related to physical rather than psychological variables.

Recognize the importance of various physical factors in training programs for squat strength.

SGLT2 inhibitors contribute to weight loss and fat reduction through glucosuria.

Incorporating SGLT2 inhibitors may aid in weight management for diabetic patients.

Obesity affects quality-of-life factors for breast cancer survivors, including sexual dysfunction, neuropathy, cardiotoxicity, chronic fatigue, and lymphedema.

Addressing obesity may improve quality of life for breast cancer survivors.

Incorporation of physical therapy, neuromuscular electrical stimulation, and early mobilization strategies may be beneficial.

Implement physical therapy and mobilization strategies in ICU care.

Resting metabolic rate decreased from 1,345 kcal·d at baseline to a low value of 1,119 kcal·d between competitions, then increased to 1,435 kcal·d by the end of recovery.

Practitioners should be aware of the potential for metabolic adaptation during contest preparation and recovery.

Obesity is linked to a significantly higher chance of early death from associated comorbidities.

Healthcare providers should monitor comorbidities in obese patients.

Active GLP-1 RA prescription was associated with a significant reduction in postoperative wound dehiscence (RR: 0.711; P = 0.001).

GLP-1 RA may be beneficial in reducing wound complications post-surgery.

Experienced MijnEetmeter users underestimated intake the least.

Encouraging users to gain experience with the app may improve dietary tracking accuracy.

Different fat depots exert different effects on the metabolic profile of individuals.

Practitioners should consider fat depot characteristics in metabolic assessments.

The mean total costs over 2 years were lower for MBS ($51,794) compared to GLP-1 receptor agonists ($63,483).

MBS may offer a more cost-effective long-term solution for obesity treatment.