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Current anti-obesity medications primarily focus on increasing satiety and reducing appetite.

Practitioners should be aware of the current focus of obesity medications when considering treatment options.

Subgroup analyses showed no effect on results when stratifying studies according to combined SJ + MJ versus MJ training alone.

Combining SJ and MJ exercises does not show a distinct advantage in hypertrophy outcomes.

Sarcopenia is associated with 1.60 to 5.80 greater odds of activities of daily living (ADL) disability.

Practitioners should consider sarcopenia as a significant risk factor for ADL disability in older adults.

Agreement between methods of operationalizing grip strength is modest.

Practitioners should be cautious about the variability in grip strength measurements when assessing sarcopenia.

The LLHR group demonstrated a trivial difference in fat free mass (FFM) favoring LLHR vs ST of 0.27 kg (95 % CI (-0.87, 1.42)).

Lighter load training may not significantly increase fat-free mass compared to traditional training.

Postoperative weight regain (WR) affects 20-30% of patients after bariatric surgery.

Clinicians should be aware that a significant portion of bariatric surgery patients may experience weight regain.

Weight regain is influenced by hormonal adaptations, including ghrelin rebound and leptin resistance.

Understanding hormonal influences can help in developing targeted interventions for weight management post-surgery.

There was a 100-fold increase in the prescription period prevalence of weight loss agents in the active component from their initial authorization date.

Practitioners should be aware of the significant increase in weight loss medication prescriptions among military personnel.

Service members in health care occupations and the Navy had higher prevalence of weight loss medication prescriptions compared to other service branches and occupations.

This information can inform targeted strategies for weight loss medication distribution within the military.

GLP-1 receptor agonists and GLP-1/GIP biagonists reduce the expression of genes involved in lipogenesis in adipose tissue.

These drugs may help in managing fat storage by altering gene expression.

Biagonists or triagonists stimulating glucagon have a more potent effect to increase thermogenesis in adipose tissue.

These drugs may be particularly effective for enhancing energy expenditure.

The number of bariatric surgeries in Germany is significantly increasing.

Healthcare providers should be aware of the growing demand for bariatric surgery.

GLP-1 receptor agonism may decrease substance use and relapse.

GLP-1 receptor agonists may be beneficial in addiction treatment.

Dual agonists targeting GLP-1 and PYY3–36 may produce synergistic effects for weight loss.

Consider dual agonist therapies for enhanced weight loss efficacy.

Gastrointestinal side effects from tirzepatide are common but mild to moderate, with less than 5% treatment discontinuation.

Practitioners should be aware of potential mild gastrointestinal side effects when prescribing tirzepatide.

GLP-1ra users have similar postoperative outcomes following body contouring surgery compared to non-GLP-1ra controls.

Practitioners can consider GLP-1ra use as not adversely affecting postoperative outcomes in body contouring surgeries.

Postoperative cellulitis occurred less frequently among GLP-1ra users in matched cohorts.

GLP-1ra use may be associated with a lower risk of postoperative cellulitis.

Wound dehiscence is more prevalent among patients taking GLP-1ras for diabetes compared to those using it for weight loss.

Consideration of the indication for GLP-1ra use may be important in assessing surgical risk.

One-year discontinuation rates for GLP-1 receptor agonists can be as high as 74% in real-world studies.

Healthcare providers should be aware of the high discontinuation rates of GLP-1 RAs in real-world settings.

The distribution of protein intake (balanced vs unbalanced) did not influence myofibrillar protein synthesis rates.

The timing and distribution of protein intake may not be critical for maximizing muscle protein synthesis in young adults.

The percent kilocalories from carbohydrate was higher in the omnivorous group compared to the vegan group.

Omnivorous diets may provide a higher carbohydrate intake compared to vegan diets, which could influence overall energy balance.

The hamstrings, iliopsoas, adductors, and tibialis anterior produced the largest downward acceleration about the center of mass.

Understanding these muscle contributions can help in designing rehabilitation programs focusing on these muscle groups.

Incretin combination therapies are being developed for the treatment of nonalcoholic fatty liver disease (NAFLD) in patients with diabetes.

Practitioners should consider the potential of incretin therapies for managing NAFLD in diabetic patients.

There were no statistically significant differences in metabolic adaptations for 24 h, sleep, or resting expenditures.

This suggests that exercise may not lead to significant changes in metabolic rates during rest or sleep.