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There were no significant differences between groups for the remaining outcomes, although a small effect size favoring TRAD was observed for the middle region of the pectoralis major (g = -0.25).

Practitioners should note that while TRAD may have a slight advantage, it is not statistically significant for all outcomes.

Using LNCSBs as a substitute for SSBs was associated with small improvements in cardiometabolic risk factors without evidence of harm.

Practitioners can consider LNCSBs as a safe alternative to SSBs for improving health outcomes.

Protein interacts with carbohydrates, fats, and dietary energy density to influence calorie intake and metabolic physiology.

Understanding protein's role can help in designing effective dietary interventions.

Considering interactions among dietary components can help reconcile different models of obesity.

Practitioners should consider dietary interactions when developing obesity interventions.

The intervention achieved 100% attendance and adherence to self-monitoring.

Practitioners can implement remote monitoring strategies to enhance adherence in older adults.

PA at months 2 to 4 was significantly correlated with PA at 1 year (rs = .29-.35, P < .01).

Early engagement in physical activity can predict long-term adherence.

Older patients were 3% more likely to have weight loss (odds ratio [OR], 1.03; 95% confidence interval [CI], 1.02–1.05).

Practitioners should consider age as a factor when assessing weight loss potential in T2D patients.

Reductions in fat mass were similar across all protein intake groups, with LP, MP, and HP showing reductions of 1.7%, 3.7%, and 3.1% respectively (P > 0.05).

Fat loss outcomes may not significantly differ based on protein intake levels in older women undergoing resistance training.

Tirzepatide achieved similar 12-month TBWL% as R-ESG (13.2% vs. 13.4%, p = .9) and significantly more than semaglutide (13.2% vs. 8.1%, p = .04).

Tirzepatide may be a viable alternative for weight loss in patients post-sleeve gastrectomy, potentially outperforming semaglutide.

The policy of Nutrition Facts added-sugar labeling is associated with a reduction of 30,000 new cancer cases and 17,100 cancer deaths among US adults over a lifetime.

Implementing added-sugar labeling could significantly reduce cancer incidence and mortality.

The policy is associated with a gain of 116,000 quality-adjusted life-years (QALYs) among US adults.

The policy could lead to significant improvements in life quality and longevity.

Additional industry reformulation to reduce added-sugar amounts would double the impact of the policy.

Encouraging food industry reformulation could significantly enhance public health outcomes.

Both FDA-approved gastric balloon systems (gas-filled IGB and fluid-filled IGB) had the same effectiveness in terms of percent total body weight loss at balloon removal.

Both balloon systems can be considered equally effective for weight loss.

The gas-filled IGB had fewer serious adverse events and better tolerability than the fluid-filled IGB.

The gas-filled IGB may be a safer option for patients.

The implementation of a pharmacist-led weight management clinic resulted in an estimated cost savings of $101,985.66.

Pharmacist involvement can lead to significant cost savings in weight management programs.

Females tended to lose more weight (Mean = 9.75) than males (Mean = 8.41).

Practitioners may consider gender differences when designing weight-loss interventions.

The semaglutide group mostly showed higher RSFC after the intervention, while the placebo group mostly showed lower RSFC in a selection of investigated ROIs.

This suggests that semaglutide may influence RSFC positively, but the clinical significance remains uncertain.

The animal-based, ketogenic diet led to increased blood ketones of ~3 mM, which is thought to suppress appetite.

Practitioners may consider the appetite-suppressing effects of ketogenic diets due to increased ketone levels.

High carbohydrate intake is associated with a higher risk of dementia (HR 1.48 (95%CI: 1.15-1.91)), while low carbohydrate intake is not significantly associated.

Practitioners should consider advising older adults to moderate their carbohydrate intake to potentially reduce dementia risk.

Moderate intakes of carbohydrate, fat, and protein are associated with the lowest risk of incident dementia.

Practitioners should encourage older adults to maintain a balanced intake of macronutrients to potentially lower dementia risk.

There were no significant differences between groups for the remaining outcomes, although a small effect size favoring TRAD was observed for the middle region of the pectoralis major (g = -0.25).

Practitioners should note that while TRAD may have a slight advantage, it is not statistically significant for all outcomes.

Discontinuation rates were strongly associated with copayment amount, increasing from 41% in the lowest quintile to 51% in the highest quintile.

Financial considerations significantly impact patient adherence to semaglutide treatment.

A higher carbohydrate quality index (CQI) is associated with greater micronutrient consumption adequacy in Iranian adults.

Encouraging higher CQI may enhance overall nutrient adequacy in dietary practices.

Minimally invasive bariatric surgeries, endoscopic procedures, fecal microbiota transplants (FMTs), and pharmaceuticals like GLP-1 receptor agonists show promising results for obesity treatment.

Practitioners should consider these innovative treatment options for obesity management.