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HIIT tends to benefit proteostasis by increasing muscle protein turnover rates.

HIIT may be a beneficial strategy for enhancing muscle health in obese individuals.

WG patients were more likely to report sustaining 12 of 12 wellness behaviors than patients who received TC.

Practitioners may consider group settings to enhance patient adherence to wellness behaviors.

The vasti, soleus, and gluteus maximus generated the largest upward accelerations of the center of mass during the barbell back squat.

Strength coaches should focus on training the vasti, soleus, and gluteus maximus for improved squat performance.

Muscle function during squatting is task and posture specific, depending on joint position and environmental interaction.

Practitioners should consider joint positions and task-specific demands when designing squat training programs.

Dual and triple agonists show effectiveness on validated surrogate NAFLD biomarkers.

There is potential for dual and triple agonists to be effective in treating NAFLD, warranting further investigation.

The dropout rate was higher in the control group (22.5%) compared to the psychological counseling group (0.0%) (p < 0.001).

Practitioners should consider the importance of psychological counseling in reducing dropout rates.

Quality of life improved among adolescents from both groups, but those in the psychological counseling group reported a better quality of life.

Psychological counseling may enhance the overall quality of life in obese adolescents undergoing treatment.

48% of individuals exhibited exercise-related energy compensation (ExEC) with a mean of −308 ± 158 kcals/day.

Practitioners should note that a significant portion of individuals may not fully compensate for exercise energy expenditure.

Exercise-related energy compensation occurs independent of metabolic adaptation.

This indicates that practitioners should not expect metabolic adaptations to accompany energy compensation from exercise.

It is questionable whether combining BFR with traditional aerobic training can preserve or potentiate hypertrophic adaptations.

Practitioners should be cautious when combining BFR with aerobic training, as the effects on hypertrophy are not well established.

GIP receptor agonism and antagonism both lead to weight reduction.

Both GIP receptor agonists and antagonists could be explored for obesity treatment strategies.

Lifestyle recommendations for nutritional care and physical activity in diabetes management are poorly implemented.

Practitioners should enhance the implementation of lifestyle interventions in diabetes care.

The macrovascular benefits of GLP-1 receptor agonists should be prioritized over potential microvascular progression of DR.

Healthcare providers should weigh the cardiovascular benefits of GLP-1 receptor agonists against the risks of worsening DR.

GLP-1RA is underutilized due to cardiologists' unfamiliarity and hesitation.

Addressing these barriers could improve GLP-1RA utilization in clinical practice.

Endoscopic sleeve gastroplasty is a novel technique of endoscopic bariatric therapies that has shown safety, efficacy, and cost-effectiveness.

Practitioners can consider endoscopic sleeve gastroplasty as a viable option for patients who are not candidates for traditional bariatric surgery.

Semaglutide treatment following catheter ablation for atrial fibrillation is associated with a lower rate of atrial arrhythmia recurrence over 12 months (hazard ratio, 0.68; P =0.030).

Practitioners may consider semaglutide as a therapeutic option to reduce atrial arrhythmia recurrence post-ablation.

Semaglutide treatment led to larger reductions in glycated hemoglobin levels compared to the control group (−1.3% vs. −0.6%; P <0.001).

Semaglutide may improve glycemic control in patients post-ablation.

Multidisciplinary combined therapy enhances the long-term efficacy of bariatric surgery.

Incorporating multidisciplinary approaches can improve patient outcomes post-surgery.

Caloric reduction may exacerbate nutrient inadequacies among adults with overweight or obesity.

Practitioners should consider the potential for nutrient deficiencies when advising caloric restriction for weight loss.

After a simulated 30% caloric reduction, 25%–40% of the population had intakes below the EAR for protein, vitamin B-6, and zinc.

Practitioners should monitor specific nutrient intakes when implementing caloric reductions.

Long-acting GLP-1 pharmacological agents have been approved for the treatment of obesity.

Practitioners can consider long-acting GLP-1 agents as viable options for obesity management.

Body mass index is associated with all-cause and cardiovascular disease mortality in both men and women.

BMI should be considered a critical factor in assessing mortality risk.

Macronutrients and micronutrients influence cardiovascular disease (CVD).

Nutritional recommendations for CVD prevention should include a focus on both macronutrients and micronutrients.

In men, a 14.4% ILI-associated increase in total testosterone at year 1 mediated increases in weight (189 g; 95% CI, 65-317) and waist circumference (0.135 cm; 95% CI, 0.19-0.248) at year 4.

Practitioners should consider the role of testosterone in managing weight and waist circumference in men with type 2 diabetes.