Browse the evidence

There is no single mode of physical activity that is superior for weight loss or prevention of weight gain.

Advise clients that various forms of physical activity can be effective for weight management, and they should choose what they enjoy.

T2DM control was satisfactory after LSG at mid- and long-term follow-up.

Laparoscopic sleeve gastrectomy is effective for long-term diabetes management in obese patients.

All exercise bouts increased mRNA expression of MYOD1 and MYF6 over time.

Engaging in exercise can enhance the expression of key myogenic factors involved in muscle growth.

Factors linked to greater weight loss on liraglutide include being female, not having diabetes, having relatively high baseline weight, and losing at least 4% of initial weight after 16 weeks of treatment.

Healthcare providers should consider these factors when predicting weight loss outcomes for patients on liraglutide.

Baseline body mass index, race, and age seem less relevant for predicting weight-loss response to liraglutide.

Providers may deprioritize these factors when assessing weight loss potential with liraglutide.

Preoperative semaglutide use in patients with type II diabetes mellitus undergoing arthroscopic rotator cuff repair was associated with a lower incidence of any adverse events (11.0% vs 27.4%), severe adverse events (3.5% vs 10.5%), and minor adverse events (8.5% vs 22.0%) within 90 days post-surgery.

Practitioners may consider semaglutide as a beneficial preoperative intervention to reduce postoperative complications in diabetic patients.

Patients not using semaglutide had a greater odds ratio of experiencing any adverse events (3.65) and severe adverse events (3.62) compared to those using semaglutide.

Highlighting the importance of semaglutide in reducing the risk of complications may guide preoperative decisions.

Patients not using semaglutide had a higher 2-year rotator cuff retear rate (18.3% vs 12.5%) compared to those using semaglutide.

This finding suggests that semaglutide may improve long-term surgical outcomes in diabetic patients.

Broad changes in the inflammatory proteome were observed among the study cohort with initial weight loss of ≈8 kg from a median 94 kg at study entry.

Practitioners should consider the role of inflammatory proteins in weight loss and maintenance strategies.

Several of the observed protein associations were also linked to prevalent obesity in the Framingham Heart Study.

Understanding these associations may inform obesity prevention strategies.

A single bout of strenuous exercise prevents the attenuation of muscle protein synthesis (MPS) response to protein ingestion caused by high-circulating lipid availability.

Incorporating strenuous exercise may enhance the effectiveness of protein intake in individuals with high lipid levels.

Exercise enhances the efficiency of skeletal muscle to utilize amino acid substrate for the postprandial anabolic response.

Exercise may improve the anabolic response to protein intake, suggesting a potential strategy for enhancing muscle growth.

Visceral obesity is correlated with cardiometabolic diseases and higher mortality.

Monitoring visceral fat levels can be crucial for assessing mortality risk.

Genetics and genomics can be used as tools to optimize weight management intervention.

Incorporating genetic and genomic insights may enhance the effectiveness of weight management strategies.

PGDP levels at the 3-month visit were positively correlated with improvements in fat mass, glycaemia, lipaemia, and liver function.

Monitoring PGDP levels may provide insights into metabolic improvements in patients undergoing treatment.

96% of overweight or obese women rated healthy diet and healthy weight before pregnancy as very important or important.

Practitioners should emphasize the importance of diet and weight management in pre-conception counseling.

77% of women favored a healthy lifestyle programme (diet, weight management and physical activity) before becoming pregnant.

Health practitioners should consider implementing lifestyle programs that align with women's preferences for pre-conception health.

77% of overweight or obese women reported being likely or highly likely to participate in specific intervention programme aspects.

Practitioners can encourage participation in intervention programs by highlighting the high interest among overweight or obese women.

Respondents tripled their average per capita consumption of whole grains and increased their fruit and vegetable intakes.

Educational interventions can lead to significant increases in whole grain and fruit/vegetable consumption among college students.

The IHM programme includes a 12-week basic training phase followed by a 9-month maintenance phase.

Practitioners should consider implementing a phased approach to lifestyle interventions.

The IHM programme incorporates web-based and physician-led health screenings.

Incorporating health screenings can enhance the effectiveness of lifestyle interventions.

Time‐dependent changes were observed for increase in trunk FFM.

Resistance training can lead to increases in trunk fat-free mass over time, regardless of supplementation.

CLA supplementation altered 57 metabolites enriched in lipids/lipid-like molecules compared to placebo.

CLA supplementation may lead to significant changes in lipid metabolism.

Baseline metabolite profiling enhanced prediction accuracy for CLA-induced body composition benefits.

Practitioners can use baseline metabolite profiles to better predict individual responses to CLA supplementation.