Browse the evidence

Baseline muscle protein synthesis (MPS) during androgen deprivation therapy (ADT) is suppressed relative to age-matched controls.

Practitioners should be aware that ADT may lead to reduced muscle protein synthesis in patients.

The implementation of MBSAQIP and ERAS protocols has significantly improved the quality of care for all bariatric patients.

Healthcare providers should adopt MBSAQIP and ERAS protocols to enhance patient outcomes.

GLP-1 RAs showed long-term protective effects on renal outcomes and adverse events.

GLP-1 RAs may provide long-term benefits for kidney health in obese individuals without T2D.

Collagen supplementation did not change integrated MPS rates compared to the RDA.

Collagen may not be effective for enhancing muscle protein synthesis in older males.

GIPR agonism may reduce gastrointestinal adverse effects associated with GLP-1R agonism.

GIPR agonists may help mitigate gastrointestinal side effects for patients using GLP-1R agonists.

Concurrent exposure to liraglutide and a GIPRA is hypothesized to produce fewer GI adverse effects than exposure to liraglutide alone.

This suggests a potential strategy for reducing side effects in patients using liraglutide.

There is limited literature on the impact of weight loss medications for plastic surgeons and their patients.

Plastic surgeons need to seek more information on the effects of these medications.

Plastic surgeons must understand the indications, contraindications, and perioperative management of weight loss medications.

Surgeons should educate themselves on these medications to ensure safe practices.

In patients with cardiometabolic HFpEF, tirzepatide showed a 58% lower risk of hospitalization for heart failure or all-cause mortality compared with sitagliptin.

Tirzepatide may also be a beneficial treatment option for patients with HFpEF and cardiometabolic conditions.

A higher BMI was associated with greater evening preference (P = 0.019).

Practitioners should consider evening preference as a factor in managing BMI in Type 2 diabetes.

Nonsignificant group differences were observed for those targeting physical activity or weight change (p > .05).

Both in-person and online coaching may not significantly differ in effectiveness for physical activity or weight management.

There is much more variation in total, activity, and basal energy expenditure among males compared to females.

Practitioners should consider the greater variability in energy expenditure among males when designing interventions.

Variation in total energy expenditure decreases with aging, more rapidly in males.

Interventions may need to adjust for age-related changes in energy expenditure variability.

The consumption of saturated fat (SFA) is not significantly associated with cardiovascular disease (CVD) risk, events, or mortality.

Practitioners can consider including SFA from nutrient-dense foods in diets without fear of increasing CVD risk.

There is no scientific ground to demonize saturated fat as a cause of cardiovascular disease.

Health professionals can reassess dietary guidelines that restrict SFA without evidence of harm.

Beneficial effects of replacing saturated fat with polyunsaturated or monounsaturated fat or carbohydrates remain elusive.

Dietary recommendations should be cautious about promoting replacements for SFA without clear evidence of benefit.

There are no significant differences in strength and muscle mass improvements between the pyramid and constant load resistance training systems.

Practitioners can choose either training method without concern for superiority in outcomes.

The study lasted 32 weeks, with 24 weeks for preconditioning and 8 weeks for the actual experiment.

Understanding the study duration helps in planning similar training interventions.

Semaglutide showed a favorable hepatic safety profile with no discontinuations due to liver enzyme elevations.

Semaglutide can be considered safe for liver health in the studied population.

Restricting benefits to allow only fruit and vegetable purchases does not improve overall dietary intake compared to unrestricted vouchers.

Policies restricting food assistance to fruits and vegetables may not lead to better dietary outcomes.

More frequent distribution of benefits (weekly versus monthly) does not lead to greater improvements in nutrition.

Increasing the frequency of food assistance distribution may not enhance nutritional benefits.

Proposed policies to restrict assistance or increase distribution frequency might not improve nutrition among low-income Americans.

Policymakers should reconsider strategies that restrict or alter the frequency of food assistance.

Type 2 diabetes is increasingly recognized as a heterogeneous condition with varying cardiovascular disease risk.

Understanding the heterogeneity of type 2 diabetes can help tailor cardiovascular risk management strategies.

Mean baseline values of REM-AHI were significantly higher than NREM-AHI in both groups.

Understanding baseline apnea severity can inform treatment approaches.