Browse the evidence

Supplementation often fails to improve protein balance or related physiological and performance outcomes under severe operational stress.

Practitioners should consider that protein supplementation may not be beneficial in high-stress operational environments.

There was no significant relationship between body fat mass changes and daily protein intake.

Practitioners should note that increasing protein intake may not affect body fat loss in older women.

In overweight and obese subjects undergoing a Mediterranean-type low-calorie diet, a different distribution of daily protein intake between meals and snacks does not result in significant differences in terms of fat mass loss and lean mass maintenance.

Practitioners can consider that protein distribution throughout the day may not significantly impact fat loss or muscle maintenance in similar dietary contexts.

ALOXE3 is activated during fasting and enhances insulin sensitivity via hepatic PPARγ.

Targeting ALOXE3 may be a viable strategy for improving insulin sensitivity in metabolic diseases.

Hepatocyte-specific ALOXE3 expression reduces weight gain and hepatic steatosis.

Enhancing ALOXE3 expression could be a strategy for reducing obesity-related liver issues.

Thiazolidinediones (TZDs) are associated with weight gain, limiting their use as first-line agents for type 2 diabetes.

Practitioners should be cautious in prescribing TZDs due to their association with weight gain.

The mortality of German type 2 diabetes (T2D) patients is approximately 3.1 times higher than that of the general population.

Healthcare providers should be aware of the significantly higher mortality risk in T2D patients compared to the general population.

The cardiovascular risk in the current DMP for T2D patients is not adequately addressed, indicating potential for improvement.

There is a need for healthcare systems to enhance cardiovascular care in T2D management programs.

Patients undergoing gastric bypass surgery have a higher risk of postoperative alcohol use disorders compared to those undergoing restrictive procedures.

Clinicians should monitor gastric bypass patients for signs of alcohol use disorders.

Twenty percent of survey respondents had a high overall score on the Eating Attitudes Test (EAT-26), indicating high rates of disordered eating behaviors.

Practitioners should be aware of the prevalence of disordered eating in this population when addressing weight loss.

All interview participants reported engaging in and/or observing disordered eating behaviors in efforts to lose weight.

Understanding the social dynamics of disordered eating can inform interventions.

Disordered eating behaviors produced ripples of embodied experiences affecting family, friends, and coworkers of dieters.

Practitioners should consider the social context of disordered eating when developing support strategies.

Concerns exist regarding the cardiovascular safety of diets, particularly related to weight fluctuations and ketogenic diets.

Practitioners should be cautious about the cardiovascular implications of certain diets.

There is currently no definitive evidence that carbohydrate reduction per se durably lowers glycaemia in type 2 diabetes.

Caution against assuming that reducing carbohydrates will always improve glycaemic control.

Medication adherence increased from 52.8% to 84%.

Encouraging medication adherence can significantly improve patient outcomes.

Pre-intervention, the score of the survey of adherence to the Mediterranean diet was relatively low (7.44 ± 0.22 points).

Understanding baseline adherence levels can help tailor interventions effectively.

In women, an ILI-associated decrease in estradiol of 14% from baseline to year 1 mediated a decline in whole-body BMD of -1.15 mg/cm2.

Practitioners should consider the hormonal changes in postmenopausal women when implementing weight loss interventions.

In men, an ILI-associated increase of 11% in total testosterone mediated a decline of hip BMD of -1.18 mg/cm2.

Practitioners should consider the hormonal changes in older men when implementing weight loss interventions.

ILI-associated changes in estradiol and total testosterone resulted in whole-body and hip bone loss.

Weight loss interventions may lead to hormonal changes that affect bone health in older adults.

The concept of diabesity is based on the twin epidemics of obesity and diabetes.

Healthcare providers should understand the link between obesity and diabetes in managing diabesity.

Lipotoxicity and inflammation cause insulin resistance in the liver and muscle.

Understanding these mechanisms can aid in developing treatment strategies for insulin resistance.

An increase in carbohydrate intake at the expense of fat intake is believed by some authors to be responsible for the obesity epidemic in North America and parts of Europe.

Practitioners should consider the implications of carbohydrate and fat intake on obesity.

Obesity rates are rising in China despite a shift from a traditional low-fat, high-carb diet to a relatively high-fat, lower-carb diet.

Practitioners should be cautious about attributing obesity solely to dietary macronutrient composition.

The T2D prediction model achieves 95.27% ROC-AUC, with 88.48% sensitivity and 87.19% specificity.

The model can be effectively used for early detection of T2D in diverse populations.