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GLP-1 receptor agonists have shown remarkable weight loss potential comparable to bariatric interventions.

GLP-1 receptor agonists may be a viable non-invasive alternative for weight loss in some patients.

Tirzepatide offers superior glycemic control and weight reduction compared to conventional GLP-1 receptor agonists.

Practitioners may consider Tirzepatide as a more effective option for managing glycemic control and weight in patients with T2DM.

Clinical trials have demonstrated effectiveness in lowering HbA1c and body weight.

Evidence from clinical trials supports the use of Tirzepatide for improving glycemic control and reducing body weight.

Exenatide combined with Metformin significantly reduced insulin resistance (HOMA-IR) by a mean difference of -0.9 (p < 0.001).

Practitioners may consider the combination of Exenatide and Metformin as an effective treatment for improving insulin resistance in women with PCOS.

Exenatide combined with Metformin reduced body mass index (BMI) by a mean difference of -0.4 (p = 0.03).

The combination therapy may assist in weight management for women with PCOS.

Several moderately sized meals spread over the day may result in greater muscle anabolism compared with the same amount of protein consumed in less frequent but bigger meals.

Practitioners should consider recommending multiple moderate protein meals throughout the day for better muscle anabolism.

Patients experienced an average weight loss of 16.06 ± 7.6 pounds at 12 weeks and 38.82 ± 11.4 pounds at 24 weeks.

Practitioners can expect significant weight loss in patients using compounded GLP-1 ± GIP agonists.

All secondary cardiometabolic outcomes improved significantly throughout the study.

Practitioners can consider compounded GLP-1 ± GIP agonists as effective for improving various cardiometabolic risk factors.

Several newer anti-obesity medications (AOMs) have been shown to reduce body weight significantly.

Clinicians can consider newer AOMs as effective options for weight management in obese patients.

Intensive lifestyle modification and medications that improve insulin resistance are key strategies for preventing type 2 diabetes (T2D).

Practitioners should focus on lifestyle changes and medications to prevent T2D.

The addition of 500 kcal·d −1 from whole foods/snacks in combination with a rigorous resistance training program promotes a weight gain of ~0.22 kg·wk −1, primarily as lean body mass, over 10 weeks in both male and female athletes.

Athletes looking to gain weight should consider increasing their caloric intake by 500 kcal·d −1 along with a structured resistance training program.

The peanut-based whole foods/snacks group gained less total body mass compared to the high-carbohydrate, peanut-free snack group.

Athletes may need to consider the type of snacks they consume for optimal weight gain results.

35% of protein supplement users take them for muscle mass increase.

Practitioners should emphasize muscle gain in discussions about protein supplementation.

Carbohydrate intake was below the recommended range for power athletes at each timepoint.

Athletes should increase carbohydrate intake to meet performance needs.

A very low-energy diet is an effective method for achieving glycaemic control and weight loss.

Implementing very low-energy diets may benefit patients with diabetes and obesity preoperatively.

Bariatric-metabolic procedures can improve and induce remission of diabetes mellitus.

Consider bariatric-metabolic procedures as a treatment option for patients with diabetes.

Consuming adequate calories, protein, and micronutrients is vital for supporting muscle mass, muscle strength, and physical function as we age.

Practitioners should emphasize the importance of adequate nutrition in older adults to support muscle health.

Without sufficient nutrition, older people put themselves at an increased risk of developing sarcopenia.

Practitioners should monitor nutritional intake in older adults to prevent sarcopenia.

Nutritional supplementation may be important to ensure older individuals have good physical health.

Practitioners should consider recommending nutritional supplements for older adults to enhance physical health.

Lifestyle measures such as increasing physical activity and improving diet are considered the basis of any drug therapy for dyslipidemias.

Practitioners should prioritize lifestyle interventions in managing dyslipidemias.

Meal replacements (MRs) lead to a significant reduction in fasting blood sugar (FBS) by 3.10 mg/dL.

Incorporating meal replacements can effectively lower fasting blood sugar levels.

The RESTART trial aims to evaluate whether a complex lifestyle intervention can improve and maintain cardiorespiratory fitness, muscle strength, and body composition among older adults with elevated cardiometabolic risk.

Practitioners can consider implementing complex lifestyle interventions to improve fitness and health in older adults at risk.

Secondary and tertiary outcomes include parameters such as muscle strength, physical activity levels, body composition, and health-related quality of life.

Practitioners should consider these additional outcomes when evaluating the impact of lifestyle interventions.

Weight decreases of 1.0% to 2.9%, 3.0% to 4.9%, and 5.0% or greater are associated with a lower risk of type 2 diabetes by 16%, 25%, and 26%, respectively.

Encouraging weight loss can significantly reduce the risk of developing type 2 diabetes.