Browse the evidence

Factors that facilitate the provision of dietary pattern advice for T2DM include social support, educational resources, and robust scientific evidence.

Enhancing support and resources can improve the effectiveness of dietary advice for T2DM.

Exercise has emerged as a potent therapeutic in disease states characterized by the accelerated aging phenotype.

Implementing exercise programs can be crucial for managing diseases associated with aging.

Semaglutide 2.4 mg was associated with significantly greater weight loss compared to placebo in clinical trials lasting 68 weeks.

Semaglutide can be considered an effective pharmacotherapy for weight loss in adults with obesity or overweight.

Reduced resistance training volume from three to one set per exercise for 8 weeks seems sufficient to retain neuromuscular adaptations in older women.

Practitioners can consider reducing training volume to one set while maintaining effectiveness for older women.

An increase in muscular strength (16.3-32.1%) and lean soft-tissue (3.2-7.9%) was observed after the pre-conditioning phase.

The pre-conditioning phase is effective for improving strength and lean mass in older women.

Advances in metabolic surgery, pharmacologic therapy, and lifestyle modification have made remission of diabetes more feasible.

Healthcare providers should consider these advancements when discussing treatment options.

Both training groups (MC and UT) experienced significant increases in strength in the bench press (BP) and squat (SQ).

Both menstrual cycle-based and traditional training can effectively increase strength in trained women.

The menstrual cycle-based training group (MC) showed a significant improvement in countermovement jump (CMJ) performance.

Incorporating menstrual cycle considerations may enhance explosive strength training outcomes.

Meal replacement (MR) significantly reduced glycated hemoglobin A1c (HbA1c) by -0.46%, fasting blood glucose (FBG) by -0.62 mmol/L, body weight by -2.43 kg, and body mass index (BMI) by -0.65 compared to conventional diabetic diets (CDs).

Implementing meal replacement strategies can lead to significant improvements in glycemic control and weight management for T2D patients.

Total meal replacement showed greater improvement in HbA1c, FBG, body weight, and BMI compared to partial meal replacement.

Total meal replacement may be more effective than partial meal replacement for improving health markers in T2D patients.

Meal replacement with caloric restriction resulted in greater reductions in body weight and BMI compared to meal replacement without caloric restriction.

Incorporating caloric restriction into meal replacement strategies can enhance weight loss outcomes for T2D patients.

NN1706 treatment led to 8.2% weight loss from baseline after 10 weeks in adults with overweight/obesity.

NN1706 may be an effective treatment option for weight loss in adults with overweight or obesity.

Whey protein supplementation reduces spine muscle atrophy more than exercise alone during spaceflight simulation.

Incorporating whey protein supplementation may enhance the effectiveness of exercise in preventing muscle atrophy during prolonged bed rest.

Participants in the DSMES program experienced significant reductions in weight, BMI, and A1C levels.

Implementing a community-based DSMES program can lead to significant health improvements in patients with type 2 diabetes.

Effective obesity management is essential to mitigate associated comorbidities and improve quality of life in menopausal women.

Healthcare providers should prioritize obesity management in menopausal women to enhance their health outcomes.

Tailored treatment strategies are necessary to address the unique challenges of obesity management during menopause.

Practitioners should develop individualized obesity management plans for menopausal women.

The ELM trial tests the hypothesis that a habit-based lifestyle treatment can produce sustained remission of metabolic syndrome (MetS) at 24 months.

Practitioners may consider implementing habit-based lifestyle interventions for MetS management.

Both GLP-1RAs and combination therapy resulted in significant weight loss, with GLP-1RAs showing a mean weight loss of −5.2 kg at 12 months.

Practitioners can expect GLP-1RAs to aid in weight management for liver transplant recipients with diabetes.

VLCHF and LF diets with moderate energy restriction demonstrate similar weight loss and improvements to BP to 3 months.

Both VLCHF and LF diets can be effective for weight loss in the short term.

All groups achieved significant weight loss and improvements in BP and blood glucose.

Both VLCHF and LF diets can lead to significant health improvements.

The automated, online, behavioral obesity treatment program (Rx Weight Loss) produced a mean estimated weight loss of 3.60 kg at 3 months.

Practitioners can consider automated online programs as effective for initial weight loss.

At 12 months, weight regain was significantly less in the monthly and refresher maintenance groups compared to the newsletter control group.

Ongoing maintenance interventions are essential to prevent weight regain after initial weight loss.

The pragmatic implementation of the Rx Weight Loss program resulted in clinically significant weight loss over 2 years.

Clinicians can implement automated online obesity treatments for sustained weight management.

A 28-day carbohydrate-restricted diet resulted in a decrease in body fat by approximately 2.4 kg.

Implementing a carbohydrate-restricted diet may help firefighters reduce body fat.