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Glucagon coagonists like survodutide and mazdutide have demonstrated significant weight loss and improved glycemic control.

These agents may be effective options for patients needing weight loss and glycemic control.

The estimated load at 0 velocity (LD0) was predictive of 1 repetition maximum (1RM), explaining 70.2% of its variance.

LD0 can be used as a reliable predictor for assessing 1RM in training settings.

Combining the slope of the individual load-velocity profile (LVP) with LD0 increased the prediction power of 1RM to 84.4%.

Incorporating the slope of the LVP can enhance the accuracy of 1RM predictions in training.

All subjects had a greater 1RM with the hook grip than with the closed grip (P < .001, effect size [ES] = 0.43).

Using the hook grip can enhance maximum lifting performance in trained individuals.

Peak velocity, peak power, peak force, and catch height were significantly greater when using the hook grip at all or most of the submaximal intensities.

Athletes may achieve better performance metrics at submaximal loads using the hook grip.

GLP-1 receptor agonists produce significant weight loss.

Practitioners can consider GLP-1 receptor agonists as a viable option for weight loss in patients with obesity.

Regular exercise promotes, maintains, and restores healthy functioning of nearly every physiological system of the human body.

Practitioners should encourage regular exercise as a key component of health maintenance.

Technology-based weight-loss maintenance interventions (WLMIs) are more likely to be effective than usual care.

Practitioners may consider technology-based interventions as a viable option for weight loss maintenance.

Protein supplementation after exercise improves fat-free mass by 0.54 kg and skeletal muscle mass by 0.34 kg compared to placebo.

Practitioners should recommend protein supplementation after exercise to enhance muscle mass.

Protein supplementation at night improves handgrip strength by 2.85 kg and leg press strength by 12.12 kg compared to placebo.

Practitioners should consider recommending protein supplementation at night to improve strength.

Milk proteins, red meat, and mixed protein are effective for gains in both muscle mass and strength.

Practitioners should prioritize milk proteins and red meat in dietary recommendations for muscle gain.

Participants in the financial incentives group lost a mean of 5.4 lb, those in the environmental strategies group lost a mean of 2.2 lb, and the combination group lost a mean of 2.4 lb more than participants in the usual care group at 18 months.

Financial incentives may lead to greater weight loss compared to usual care, but the overall effectiveness is not significantly different.

Employees with obesity may benefit from more intensive individualized weight loss strategies.

More personalized approaches may enhance weight loss outcomes for individuals with obesity.

Both the narrow repetition zone (NPR) and wide repetition zone (WPR) in a pyramid system increased skeletal muscle mass (SMM) in older women, with NPR showing a +4.7% increase and WPR showing a +8.4% increase.

Resistance training using a pyramid system can effectively enhance muscle mass in older women.

Both the narrow repetition zone (NPR) and wide repetition zone (WPR) in a pyramid system increased total strength in older women, with NPR showing a +11.3% increase and WPR showing a +13.8% increase.

Implementing a pyramid training system can significantly improve strength in older women.

Whey protein supplementation resulted in a greater increase in vastus lateralis muscle thickness (8.4 ± 2.5%) compared to leucine-matched collagen peptides (5.6 ± 2.6%) after a 10-week resistance training program.

Practitioners should consider whey protein as a more effective supplement for increasing muscle thickness in untrained individuals.

Whey protein supplementation led to a greater increase in biceps brachii muscle thickness (10.1 ± 3.8%) compared to leucine-matched collagen peptides (6.0 ± 3.2%) after a 10-week resistance training program.

Whey protein may be more effective than collagen peptides for increasing biceps muscle size in untrained individuals.

There was a similar increase in muscle performance (peak torque, mean power output, and peak power output) between whey protein and leucine-matched collagen peptides groups after the resistance training program.

Both whey protein and collagen peptides can enhance muscle performance similarly in untrained individuals.

Sustained improvements were noted in body mass (-7.6 %), HbA1c (-0.3 %), triglycerides (-18.4 %), HDL-C (+17.4 %), and inflammatory markers.

Practitioners can expect significant improvements in metabolic health markers with this dietary approach.

At 8 weeks, there were significant differences among groups for all macronutrients and many micronutrients (p<0.0001).

Dietitians should consider the differences in nutrient intake when recommending weight loss diets.

GLP-1 receptor agonists (GLP-1RAs) have proven efficacy in glucoregulation and weight loss.

Practitioners can consider GLP-1RAs as effective treatment options for managing diabetes and obesity.

Tirzepatide facilitated unprecedented weight loss of up to 22.5% in non-diabetic individuals living with obesity.

This indicates that tirzepatide can be a significant option for weight management in obese individuals.

Tirzepatide provides glycemic lowering and weight loss effects.

Tirzepatide may be effective for patients needing to lower blood sugar and lose weight.

Exercise is a first-line prevention and intervention strategy for type 2 diabetes.

Practitioners should prioritize exercise as a key component in diabetes prevention and treatment.