Browse the evidence

The activation of GIPR by LAGIPRA or THDBH120 alleviated inflammation.

GIPR activation may be beneficial for reducing inflammation in obesity-related conditions.

Tirzepatide is associated with lower mortality compared to both semaglutide and SGLT2 inhibitors.

Tirzepatide may offer a survival advantage for patients with type 2 diabetes.

GLP-1 receptor agonists (GLP-1 RAs) have demonstrated anti-inflammatory, antioxidative, and immunomodulatory properties.

GLP-1 RAs may be beneficial in managing inflammation and immune responses.

The use of dual and triple agonists was associated with a higher risk of any adverse events (RR 1.13; 95% CI: 1.08-1.19).

Clinicians should be aware of the potential for increased adverse events when prescribing incretin polyagonists.

KN069 was well tolerated, with predominantly mild-to-moderate gastrointestinal adverse events.

KN069 may be a safe option for weight management in this population.

Obesity and obstructive sleep apnea (OSA) contribute to cardiovascular disease through interconnected mechanisms.

Practitioners should consider the combined effects of obesity and OSA when addressing cardiovascular health.

GLP-1 RA use was associated with significantly lower occupational therapy utilization (RR = 0.686, p < 0.011).

GLP-1 RAs may reduce the need for occupational therapy in rotator cuff repair patients.

Muscle volume decreased in the injured muscle compared to the contralateral healthy muscle during the intervention by −9.4% (−13.5% to −5.3%), p < 0.0001, and this decrease persisted at 12 months.

Rehabilitation programs should consider the persistent loss of muscle volume after strain injuries.

There was a persistent increase in aponeurosis volume associated with the injured muscle at 3 months and 12 months, but it was unaffected by protein supplementation.

Increased aponeurosis volume may indicate structural changes in muscle healing, regardless of protein intake.

Neither collagen nor whey protein ingestion further increased muscle connective protein synthesis rates during the early stages of post-exercise recovery.

Collagen protein may not be effective for enhancing muscle connective tissue recovery post-exercise.

The low-intensity resistance training program may be insufficient for increasing muscle strength and mass among both young and older adults.

Low-intensity resistance training may not be adequate for rehabilitation goals related to muscle strength.

In insulin resistance, endothelin-1 is directly involved in regulating muscle glucose uptake.

Understanding the role of ET-1 may help in developing targeted therapies for insulin resistance.

The concept of diabesity is based on the twin epidemics of obesity and diabetes.

Healthcare providers should understand the link between obesity and diabetes in managing diabesity.

Lipotoxicity and inflammation cause insulin resistance in the liver and muscle.

Understanding these mechanisms can aid in developing treatment strategies for insulin resistance.

Age-related insulin resistance arises from interconnected mechanisms, including inflammaging, cellular senescence, and mitochondrial dysfunction.

Understanding these interconnected mechanisms can help in developing targeted interventions for older adults.

Muscle metabolic quality, rather than adiposity alone, emerges as a key determinant of insulin sensitivity in older adults.

Emphasizing muscle quality in interventions may improve insulin sensitivity in older patients.

Innovative obesity therapies could transform long-term outcomes of preeclampsia.

Practitioners should stay informed about new obesity therapies that may improve long-term health outcomes for women with preeclampsia.

Modern research has identified various factors that modulate insulin resistance, indicating the need for targeted therapies.

Identifying modulating factors can help in developing personalized treatment strategies for insulin resistance.

The visual-textual integrator of iFood achieved an accuracy of 51.38% in identifying diet images and information.

The accuracy of the app's data integration can be improved for better dietary insights.

Age was the only consistent demographic effect across time points.

Age should be considered when designing interventions for behavior change.

Data from supercentenarians can provide insights into the contributions of genetics, lifestyle choices, and epigenetics to longevity.

Research on supercentenarians can guide future studies on aging and longevity.

Smokers had much lower plasma levels of beta-carotene than did nonsmokers (geometric mean 8.5 vs. 15.3 micrograms/dl for men; 17.3 vs. 26.3 micrograms/dl for women).

Practitioners should consider the impact of smoking on beta-carotene levels when assessing nutritional status.

The correlation of calorie-adjusted intake of vitamin E with lipid-adjusted plasma levels of vitamin alpha-tocopherol was 0.53 for men and 0.51 for women.

Practitioners should note the importance of vitamin E intake for maintaining adequate plasma levels.

Higher frequency of aspirin intake was associated with an increasing prevalence of constipation (PR = 1.38, 95% CI = 1.17-1.62).

Caution may be needed regarding aspirin use as it may contribute to constipation.