Browse the evidence

Obesity is characterized by adipose tissue dysfunction, insulin resistance, chronic low-grade inflammation, and gut microbiota dysbiosis.

Understanding these characteristics can help in developing targeted interventions for obesity.

Greater achieved weight loss during the landmark period did not show a consistent association with lower post-landmark cardiovascular risk.

Weight loss alone may not be sufficient to reduce cardiovascular risk, emphasizing the importance of medication dosage.

The study drug was well tolerated, and no serious adverse events were reported.

Practitioners can consider semaglutide safe for use in healthy individuals based on this study.

Tirzepatide can cause acute hepatocellular liver injury in patients.

Clinicians should monitor liver function in patients using tirzepatide.

Symptoms of liver injury resolved and liver enzymes normalized within 3 weeks of presentation.

Patients may recover from tirzepatide-induced liver injury with appropriate monitoring.

HMB supplementation failed to demonstrate significant benefits for muscle strength (SMD = -0.22, 95% CI: -0.57, 0.12) or mass outcomes (MD = 0.05, 95% CI: -0.33, 0.44).

HMB supplementation may not be effective for improving muscle strength or mass in older adults.

Common side effects of all GLP-1-agonists include an increased risk of gastrointestinal and gallbladder-related complaints.

Clinicians should be aware of potential gastrointestinal and gallbladder-related side effects when prescribing GLP-1-agonists.

Anti-obesity vaccines face significant immunological and regulatory challenges.

Understanding these challenges is crucial for developing effective anti-obesity vaccines.

The most common adverse reactions associated with tirzepatide are gastrointestinal disorders.

Healthcare providers should inform patients about potential gastrointestinal side effects when prescribing tirzepatide.

If not detected and treated early, MASLD can progress to fibrosis and hepatocellular carcinoma.

Early detection and treatment of MASLD are crucial to prevent serious complications.

Tirzepatide reverses β-cell dedifferentiation in HFD-fed mice.

Tirzepatide may help restore β-cell function by reversing dedifferentiation in diabetic conditions.

GLP-1 RA-induced gastroparesis can increase the risk of aspiration during ophthalmic surgery.

Surgeons should be aware of the aspiration risk in patients using GLP-1 RAs.

GLP-1R agonists can improve cardiac contractility in human hearts.

Practitioners may consider GLP-1R agonists as a potential treatment to enhance heart contractility.

Epicardial adipose tissue may contribute to arrhythmogenesis through pro-inflammatory and pro-fibrotic effects.

Addressing epicardial adipose tissue may be important in managing arrhythmias in obese patients.

Adipositas ist eine multifaktorielle Erkrankung mit global steigender Prävalenz.

Practitioners should recognize the multifactorial nature of obesity when addressing it in patients.

Wash-in and washout effects can threaten the validity of short-term dietary trials.

Researchers should consider the timing of interventions and outcomes in dietary trials to ensure validity.

Higher BMI was associated with a different airway shape, including larger minimum anteroposterior distance and smaller minimum lateral distance.

Understanding the changes in airway shape with BMI can help tailor OSA treatment strategies.

A better understanding of antidiabetic drugs' effects on skeletal muscle lipid metabolism is needed.

Future research should prioritize understanding how antidiabetic drugs affect lipid metabolism in skeletal muscle.

Obesogenic stimuli promote adipose tissue macrophages to recruit neutrophils from the bone marrow in mice.

Understanding neutrophil recruitment can inform strategies to manage inflammation in obesity.

Inhibiting neutrophil recruitment out of the bone marrow in obese mice or during weight loss reduces bone marrow myelopoiesis and adipose tissue inflammation.

Targeting neutrophil recruitment may help reduce inflammation during obesity management.

In humans with obesity, plasma neutrophil chemokines are increased and correlate with increased insulin resistance, but do not decrease with weight loss.

Monitoring neutrophil chemokines may provide insights into insulin resistance in obese patients.

Effective nephroprotection requires early identification of at-risk patients through screening.

Implement routine screening for CKD risk factors in clinical practice.

Cheeses improved C. elegans lifespan, mobility with aging, and age-related muscle degradation.

Incorporating these cheeses may support longevity and mobility in aging populations.

MitoQ supplementation did not impact mitochondrial respiration or H2O2 emission in the presence of ADP.

MitoQ does not enhance mitochondrial function during exercise in older adults.