Browse the evidence

Community-based lifestyle interventions to manage excess weight can be successfully conducted in Indigenous Australians, but with generally limited efficacy.

Practitioners should consider implementing community-based lifestyle programs, while being aware of their limited effectiveness.

The effect of lifestyle programs on weight reduction was modest (∼2-4 kg after 4-12 months).

Weight loss from lifestyle programs may be limited, and practitioners should set realistic expectations.

Tirzepatide achieves unprecedented weight loss, but case reports suggest potential sexual side effects.

Clinicians should monitor for potential sexual side effects in patients using Tirzepatide for weight loss.

Non-Hispanic Black (NHB) participants had lower percent total weight loss (%TWL) at 3, 12, and 24 months compared with Hispanic (H) and non-Hispanic White (NHW) participants.

Healthcare providers should consider racial and ethnic differences when evaluating weight loss outcomes post-surgery.

Tirzepatide produced meaningful weight loss across groups, but outcomes varied based on weight-reduction status and T2D status.

Practitioners should consider individual patient factors when prescribing tirzepatide for weight loss.

The S3 guideline for the prevention and treatment of obesity includes new recommendations on stigmatization, diagnostics, and therapy, incorporating areas like E-Health.

Practitioners should consider the new recommendations in their approach to obesity treatment.

The treatment of obesity is undergoing significant changes due to new weight-reducing medications, innovations in intervention, digital therapy options, and political decisions.

Practitioners should be aware of the evolving landscape of obesity treatment options.

There are no significant differences in muscle mass and strength gains between consuming protein three or five times a day.

Practitioners can advise that both three and five protein meals are effective for muscle gain.

Adherence to recommended dosage and seeking medical advice regarding possible side effects/interactions is recommended.

Practitioners should advise patients to follow dosage guidelines and consult healthcare providers.

Approximately 1-in-10 participants met the resistance training guidelines.

Only a small fraction of the population adheres to recommended resistance training guidelines.

The study will evaluate both quantitative and qualitative effects of the SALUD program.

The dual evaluation approach can provide comprehensive insights for T2DM interventions.

Metabolic bariatric surgery is associated with durable weight loss and lower observed rates of major adverse cardiovascular events (MACE), heart failure, and all-cause mortality compared with non-surgical care.

Practitioners can consider metabolic bariatric surgery as an effective option for achieving weight loss and reducing cardiovascular risks.

The incidence of using hypoglycemic drugs was 36.15% in the plate model compared to 75.54% in the low-fat model (P<0.001).

Implementing the plate model may significantly reduce the need for hypoglycemic medications in newly diagnosed type 2 diabetes patients.

A median SPAN score (52.8) was associated with a 41% lower risk of MACE (HR: 0.59; 95% CI: 0.49, 0.70).

Practitioners should aim for a balanced SPAN score to lower cardiovascular event risk.

The quality of lipids improved in women and among individuals reporting some away-from-home food consumption.

Practitioners should note that lipid quality may improve with certain consumption patterns, particularly in women.

A healthy omnivorous diet can lead to comparable clinical lab outcomes as a healthy vegan diet.

Health professionals can recommend a healthy omnivorous diet as an alternative to vegan diets for similar health outcomes.

The study involved identical twins who consumed an omnivorous diet before enrollment.

Understanding the dietary background of participants is crucial for interpreting the results.

Latina women experiencing food insecurity consumed fewer vegetables compared to those with food security (1.7 vs. 3.0 servings, p=0.02).

Practitioners should address food security to improve vegetable intake among Latina women.

Women with nutrition insecurity consumed fewer servings of vegetables compared to participants with nutrition security (1.7 vs. 2.5 servings, p=0.01).

Practitioners should focus on improving nutrition security to enhance vegetable intake.

Adherence to vegan and WFPB diets for ≥2 years is associated with lower BMI compared to <2 years.

Long-term adherence to vegan and WFPB diets may enhance weight loss outcomes.

Some patients may require weight loss beyond what lifestyle and behavioral modification can achieve.

Recognize that some patients may need additional interventions beyond lifestyle changes.

A ≥15% BMI reduction was associated with a 33% reduction in group health insurance payments at year 1.

Employers may see significant healthcare cost savings by supporting weight loss programs for employees.

Employees who lost ≤5% BMI had a 10% reduction in health expenditures.

Even modest weight loss can lead to some healthcare cost reductions.

Obesity is a chronic disease with significant physical and psychological impairments.

Practitioners should recognize obesity as a serious chronic condition requiring comprehensive management.