Browse the evidence

Increased waist circumference (WC) during the first year of intensive lifestyle intervention (ILI) is associated with a higher risk for subsequent cardiovascular outcomes, independent of weight change.

Practitioners should monitor waist circumference in patients undergoing lifestyle interventions for diabetes management.

ILI participants with increased waist circumference had an increased risk of primary cardiovascular outcomes, regardless of weight loss or weight gain.

Weight management strategies should also focus on waist circumference reduction to mitigate cardiovascular risks.

Tirzepatide induced a mean absolute HbA1c reduction across the three doses ranging from 2.3% to 3.0% in East Asian participants with type 2 diabetes.

Tirzepatide is effective in reducing HbA1c levels in East Asian individuals with type 2 diabetes.

Metabolic adaptation plays a relevant role in the management of obesity and human weight loss.

Practitioners should consider metabolic adaptation when designing weight loss interventions.

GLP-1 receptor agonists (GLP-1 RAs) may improve obstructive sleep apnea (OSA) symptoms by reducing fat deposition around the upper airway and decreasing systemic inflammation.

Practitioners may consider GLP-1 RAs as a potential treatment option for improving OSA symptoms in obese patients.

GLP-1 RAs may enhance traditional OSA treatments, offering an integrated approach targeting the root cause of obesity in OSA.

Practitioners should consider integrating GLP-1 RAs into OSA management strategies.

GLP-1 RAs may provide benefits for other obesity-related comorbidities, including hypertension and cardiovascular disease.

Practitioners should be aware of the potential for GLP-1 RAs to address comorbidities in obese OSA patients.

Obesity contributes to the emergence of cardiovascular risk factors such as dyslipidaemia, type 2 diabetes, hypertension, and sleep disorders.

Addressing obesity may help in managing these associated cardiovascular risk factors.

Some researchers claim that the timing of nutritional consumption may be more critical to muscle development than the absolute daily consumption of nutrients.

Practitioners should consider the potential importance of nutrient timing in relation to total daily intake for muscle development.

Bariatric surgery before liver transplantation is feasible and can improve liver function for patients on the transplant waiting list.

Bariatric surgery may be a beneficial option for patients with obesity awaiting liver transplantation to enhance liver function.

A tendency toward a greater increase in fat-free mass (FFM) was observed in the OC group (3.7 ± 3.8%) compared to nonusers (2.7 ± 3.5%), with p = 0.08.

There may be a slight advantage in fat-free mass gain for OC users, warranting further investigation.

The intake of dairy appears to have a protective effect on some cardiovascular risk factors, or it is not worse than other SFA sources.

Incorporating dairy may be beneficial for cardiovascular health compared to other saturated fats.

Dairy products seem to present a different effect on cardiometabolic risk factors than other fat sources.

Understanding the unique effects of dairy can inform dietary recommendations regarding fat sources.

Higher carbohydrate intake is associated with an increased risk of stroke (HR=1.13, 95% CI: 1.01, 1.27).

Higher carbohydrate consumption may elevate stroke risk, warranting dietary adjustments.

A high body mass index is one of the strongest risk factors for new-onset Chronic Kidney Disease.

Monitoring BMI can be crucial for preventing Chronic Kidney Disease.

Low intracellular ATP levels lead to carbohydrate-dependent hunger and impaired satiety.

Recognizing the link between ATP levels and hunger can aid in obesity treatment strategies.

Twenty percent (n = 24) of the five-year completers achieved remission from type 2 diabetes.

Practitioners can consider very low carbohydrate diets as a viable option for achieving diabetes remission.

Tirzepatide treatment resulted in a significant decrease of bodyweight compared with the vehicle treatment.

Tirzepatide may be effective for weight management in obese populations.

T2DM control was satisfactory after LSG at mid- and long-term follow-up.

Laparoscopic sleeve gastrectomy is effective for long-term diabetes management in obese patients.

Broad changes in the inflammatory proteome were observed among the study cohort with initial weight loss of ≈8 kg from a median 94 kg at study entry.

Practitioners should consider the role of inflammatory proteins in weight loss and maintenance strategies.

Visceral obesity is correlated with cardiometabolic diseases and higher mortality.

Monitoring visceral fat levels can be crucial for assessing mortality risk.

PGDP levels at the 3-month visit were positively correlated with improvements in fat mass, glycaemia, lipaemia, and liver function.

Monitoring PGDP levels may provide insights into metabolic improvements in patients undergoing treatment.

Baseline metabolite profiling enhanced prediction accuracy for CLA-induced body composition benefits.

Practitioners can use baseline metabolite profiles to better predict individual responses to CLA supplementation.

The menstrual cycle-based training group (MC) showed a significant increase in fat free mass (FFM) of 1.7 ± 1.8 kg, but this was not statistically significant (P = 0.080).

Practitioners may consider menstrual cycle-based training for potential benefits in body composition.