Browse the evidence

Sleeve gastrectomy can result in weight loss up to 23% at 1 year and is associated with a lower risk of malabsorption compared to Roux-en-Y gastric bypass.

Surgeons and healthcare providers should consider sleeve gastrectomy as a viable option for weight loss in transplant candidates.

Die Gewichtsentwicklung in den ersten Wochen bis Monaten nach Initialisierung einer Therapie ist der stärkste Prädiktor für Gewichtszunahme assoziiert mit AP und AD.

Monitoring weight in the early stages of treatment can help predict long-term outcomes.

Lower HbA1c is associated with 0.17 to 0.22 standard deviation better cognitive function across all domains.

Improving diabetes control to achieve lower HbA1c levels may enhance cognitive function in individuals with type 2 diabetes.

Diabetes mellitus is associated with nutritional and metabolic derangements that are often neglected in clinical assessments.

Healthcare professionals should prioritize nutritional assessments in diabetes management.

Tirzepatide affected metabolic parameters including body weight, adipose tissue mass, hepatic triglycerides, and circulating pro-inflammatory cytokines.

Tirzepatide may have beneficial effects on metabolic health in addition to its impact on alcohol consumption.

The balance between adipose tissue reduction and lean mass preservation with GLP-1RAs remains incompletely understood in clinical settings.

Further research is needed to clarify the effects of GLP-1RAs on body composition in clinical practice.

Semaglutide users had higher rates of pneumonia (2.97 % vs 0.85 %, p < 0.05) compared to non-users.

Clinicians should be aware of the increased risk of pneumonia in patients using semaglutide.

Patients with longer semaglutide use had a higher incidence of urinary tract infection (4.03 % vs 1.27 %, p < 0.05) and acute kidney injury (3.18 % vs 0.85 %, p < 0.05).

Healthcare providers should monitor for urinary tract infections and kidney injury in patients on long-term semaglutide.

The need for additional lumbar fusion was associated with both semaglutide use (17.0 % vs. 6.4 %, p < 0.0001) and duration (28.3 % vs. 4.8 %, p < 0.0001).

Surgeons should consider the potential for increased surgical interventions in patients using semaglutide.

Sitagliptin elicited modest glycemic improvements without substantial alterations in lipid composition.

Sitagliptin may be less effective than semaglutide for lipid management in T2DM patients.

Metabolic adaptation in energy expenditure (adaptive thermogenesis) was unrelated to the energy cost of weight and fat mass gains.

Weight gain responses may not be influenced by changes in metabolic rate during overfeeding.

Injectable pharmacotherapies are effective strategies to manage obesity by targeting metabolic pathways.

Practitioners can consider injectable pharmacotherapies as a viable option for obesity management.

Observational data show a reduction in all-cause mortality and cancer risk in patients who have undergone bariatric surgery.

Bariatric surgery may significantly improve long-term health outcomes and reduce mortality risk.

Physical frailty and sarcopenia are associated with morbidity and 2-fold mortality in patients with advanced chronic liver disease awaiting liver transplantation.

Healthcare providers should assess frailty and sarcopenia in liver transplant candidates to improve outcomes.

Loss of muscle-related indices exceeded prespecified benchmarks in two thirds of incretin-based interventions.

Clinicians should monitor muscle mass when prescribing incretin therapies for weight loss.

BMI is not sufficient to define obesity; pathophysiology and the impact of mechanical, metabolic, and psychological complications must be considered.

Practitioners should consider multiple factors beyond BMI when assessing obesity.

Up to 33% of the weight lost on GLP-1 RAs may be lean tissue mass.

Practitioners should monitor body composition changes in patients using GLP-1 RAs.

GLP-1RAs may raise safety concerns related to weight loss and altered glucose regulation in ALS.

Monitoring for weight loss and glucose regulation is essential when considering GLP-1RAs for ALS.

Excess visceral abdominal fat (EVAF) can occur in people living with HIV-1 even with normal or mildly elevated body mass index (BMI).

Healthcare providers should assess visceral fat in PLWH regardless of BMI.

Hemoglobin A1c decreased across all groups but remained consistently higher in NHB and H compared with NHW at 24 months.

Monitoring of Hemoglobin A1c levels should be tailored based on race and ethnicity post-surgery.

Non-responders to the PF regimen demonstrated only transient and limited metabolic shifts.

Understanding the differences in metabolic responses can guide dietary strategies for T2D management.

A shift towards reduced carbohydrate intake and increased dietary fat may be linked to higher morbidity and mortality rates in patients with diabetes.

Practitioners should consider the implications of dietary fat and carbohydrate ratios in diabetes management.

The majority of animal studies demonstrated a greater impact from high-fat diets compared with higher-sugar diets.

Animal studies suggest that high-fat diets may pose greater risks than high-sugar diets, informing dietary recommendations.

A plant-based diet is associated with an increased risk of higher TyG in women (OR = 1.25 for PDI and OR = 1.55 for hPDI).

Practitioners should be cautious about recommending high plant-based diets for women without considering overall dietary balance.