Browse the evidence

Long-term consumption of diets rich in dietary polyphenols (including flavonoids, phenolic acids, and stilbenes) provides protection against oxidative stress-induced chronic diseases such as neurodegenerative disorders, cardiovascular diseases, cancer, and diabetes.

Prioritize a diet rich in diverse plant foods known for high polyphenol content, such as berries, tea, coffee, dark chocolate, nuts, and olive oil. This dietary pattern is associated with reduced risk of chronic oxidative stress-related diseases. Focus on variety and long-term consistency rather than isolated high-dose supplements.

Coffee consumption (>3 cups/day) has a protective role and improves liver enzymes in individuals at risk of liver diseases.

Drinking more than 3 cups of coffee daily may help protect liver health and improve enzymes.

The Mediterranean diet, characterized by high intake of polyphenols, fiber, and omega-3 fatty acids, counteracts oxidative stress and insulin resistance in Type 2 Diabetes by activating the NRF2 antioxidant pathway and reducing pro-inflammatory eicosanoids.

Adopt a Mediterranean-style eating pattern focusing on vegetables, fruits, whole grains, legumes, nuts, and extra virgin olive oil. Limit meat and processed foods. This approach helps manage oxidative stress and insulin resistance through natural antioxidants and anti-inflammatory fats.

Supplements including Vitamin D, Resveratrol, Alpha-lipoic acid, Omega-3, Berberine, Folic acid, Myoinositol (MI), and D-chiro-inositol (DCI) are effective adjunctive therapies for PCOS, improving insulin sensitivity, lipid profiles, and ovulation.

Consider adding specific supplements to your regimen: Vitamin D (especially in cold seasons), Resveratrol, Alpha-lipoic acid, Omega-3, Berberine, Folic acid, Myoinositol, and D-chiro-inositol. These may improve insulin sensitivity and lipid profiles.

Lower circulating taurine concentrations in humans are associated with adverse health outcomes including abdominal obesity, hypertension, inflammation, and type 2 diabetes.

Maintaining healthy taurine levels through diet or supplementation might be beneficial for metabolic health, as low levels are linked to obesity and diabetes. However, more research is needed to confirm if supplementation directly improves these conditions in humans.

Selenium deficiency impairs immune function, increases susceptibility to infections (including HIV and COVID-19), and is linked to cardiovascular diseases such as Keshan disease and myocardial infarction.

Ensure adequate selenium intake through diet (e.g., Brazil nuts, seafood, meat) to support immune function and cardiovascular health. The recommended daily allowance for adults is 55 µg. Avoid excessive supplementation beyond 400 µg/day due to toxicity risks.

Excessive selenium intake (above nutritional levels) is associated with an increased risk of type 2 diabetes, insulin resistance, and dyslipidemia.

Do not exceed the tolerable upper intake level of 400 µg/day. If you are not deficient, high-dose selenium supplementation may increase your risk of type 2 diabetes and insulin resistance. Focus on food sources rather than supplements unless advised by a doctor.

Encapsulating plant polyphenols in green bio-based nanocarriers (proteins, polysaccharides, or lipids) significantly improves their oral bioavailability and stability compared to unencapsulated forms.

If you take polyphenol supplements (like green tea extract or curcumin), look for those using advanced delivery systems (like nano-encapsulation). Standard powders may pass through your system without being absorbed effectively. The technology ensures the active ingredients actually enter your bloodstream.

Long-term consumption of foods rich in plant polyphenols is associated with the prevention or improvement of chronic diseases including diabetes, cardiovascular disease, cancer, and neurodegenerative disorders.

Incorporate a variety of polyphenol-rich plant foods (fruits, vegetables, tea, coffee) into your daily diet. This long-term dietary pattern supports heart health, blood sugar regulation, and cognitive function, acting as a preventive measure against chronic diseases.

Consuming fruits and vegetables rich in antioxidants (vitamins A, C, E, carotenoids, phenolic acids, flavonoids) helps prevent diseases associated with oxidative stress, including cardiovascular disease, cancer, and neurodegenerative disorders, by neutralizing free radicals and reducing oxidative stress.

Eat a variety of fruits and vegetables daily to get natural antioxidants. Focus on colorful produce like oranges, tomatoes, apples, and leafy greens, as they contain high levels of vitamins and polyphenols that help protect your body from cellular damage and reduce the risk of chronic diseases like heart disease and cancer.

Supplementation with phenolic compounds (polyphenols) reduces oxidative stress and inflammation markers induced by severe physical exercise, but does not consistently improve physical performance outcomes.

If you engage in intense exercise, polyphenol supplementation (from foods like berries, tea, or chocolate) can help manage oxidative stress and inflammation. However, do not expect this to directly make you faster or stronger; the evidence for performance enhancement is inconsistent.

Synbiotics (combining probiotics and prebiotics) improve the survival and efficacy of probiotics in the gastrointestinal tract compared to probiotics alone.

If you take probiotics, consider a synbiotic formulation that includes prebiotics (like oligosaccharides). This combination helps the probiotic bacteria survive stomach acid and colonize the gut more effectively.

Quercetin supplementation has no significant effect on Interleukin-6 (IL-6) concentrations after exercise.

Do not expect quercetin to significantly lower IL-6 levels post-exercise based on current meta-analytic data.

Neuropilin-1 (NRP-1) plasma levels are inversely associated with fasting plasma triglycerides, and changes in NRP-1 during exercise are inversely correlated with changes in triglycerides.

This paper identifies a new potential biomarker, Neuropilin-1 (NRP-1), which is linked to triglyceride levels. While not a direct treatment, monitoring NRP-1 might help understand how exercise affects lipid metabolism in MetS patients. Lower NRP-1 changes are associated with greater triglyceride reductions.

Omega-3 fatty acid supplementation does not significantly alter ALT levels in individuals with MASLD.

Taking Omega-3 fatty acid supplements does not significantly lower liver enzymes (ALT) in people with MASLD compared to control groups. While Omega-3s are generally healthy, they should not be relied upon as a primary treatment for improving liver health biomarkers in this condition.

Quercetin and Resveratrol supplementation do not improve physical performance or recovery markers in military personnel.

Do not rely on Quercetin or Resveratrol for performance or recovery benefits. They do not improve aerobic capacity or physical performance in military personnel.

Specific fatty acid esters of hydroxy fatty acids (FAHFAs), particularly 5-PAHSA and 9-PAHSA, improve insulin sensitivity and glucose-stimulated insulin secretion.

Research shows that specific fatty acid derivatives called FAHFAs (like 5-PAHSA) can improve how your body handles insulin and glucose. However, this is currently based on animal studies and human observational data, not proven clinical treatments. Do not self-prescribe specific isomers until more clinical trials are available.

In 60–65-year-old women, higher intake of long-chain polyunsaturated fatty acids (PUFA) is negatively correlated with skeletal muscle mass, contrary to some previous literature suggesting protective effects.

For women aged 60-65, do not assume that high PUFA intake guarantees muscle preservation. This study found a negative correlation, possibly because those with lower muscle mass increase PUFA intake to compensate. Focus on protein intake and moderate activity as primary drivers.

High-protein diets (>1.6-2.2 g/kg body weight) and excessive protein supplementation may negatively alter gut microbiota by increasing toxic metabolites (ammonia, amines) through proteolytic fermentation, potentially reducing probiotic strains.

If you are a strength athlete consuming high protein (>2g/kg), monitor your gut health. Excessive protein can lead to toxic byproducts like ammonia. Consider mixing protein sources (e.g., adding soy or plant proteins) and ensuring adequate fiber intake to support probiotic bacteria and reduce gut stress.

Among Malaysian reproductive-age women (35-49 years), dietary intakes of calcium, magnesium, phosphorus, vitamin K, and vitamin C are not significantly associated with the risk of bone fractures.

For women aged 35-49, ensuring high intake of calcium, magnesium, phosphorus, vitamin K, and C does not appear to statistically lower fracture risk in this population, according to this study. Instead, managing diabetes and avoiding passive smoking are more critical factors for bone health. Focus on overall health management rather than just micronutrient supplementation for fracture prevention.

Coffee consumption (caffeinated and decaffeinated) is inversely associated with liver fibrosis, abnormal liver function tests, and hepatocellular carcinoma risk in NAFLD patients.

If you tolerate it, drinking coffee (caffeinated or decaf) may help protect your liver from scarring and cancer. It is a simple, low-cost addition to a liver-healthy lifestyle.

Stevia-derived Rebaudioside A improves liver steatosis, fibrosis, and glucose metabolism in NAFLD/NASH models by modulating gut microbiota and reducing oxidative stress.

For individuals with NAFLD or NASH, using Stevia (specifically Rebaudioside A) as a sweetener replacement for sugar may improve liver health, reducing fat accumulation and fibrosis, and improving glucose metabolism. This is achieved through positive changes in gut microbiota and reduced oxidative stress.

Moderate and frequent consumption of coffee is associated with a decreased risk of NAFLD and fibrosis, likely through the stimulation of hepatic stellate cell apoptosis and suppression of collagen synthesis.

Drinking at least one cup of coffee daily (moderate consumption) is associated with a lower risk of developing NAFLD and fibrosis. It may also improve liver function by lowering liver enzyme levels. This benefit is attributed to caffeine and chlorogenic acid.

Traditional Asian dietary practices, including the consumption of ulam, probiotics from fermented foods, and herbs like curcumin and green tea, reduce dementia risk through anti-inflammatory and gut-brain axis mechanisms.

Incorporate more fermented foods (yogurt, kimchi, miso), herbs like turmeric and green tea, and leafy vegetables into your diet. These support gut health and reduce inflammation, which benefits brain health.