Browse the evidence

Statin-induced suppression of prenyl intermediates in the cholesterol biosynthetic pathway has been linked to stimulated atherosclerosis and heart failure.

Practitioners should be cautious about the long-term cardiovascular effects of statin use.

Innovative drug delivery systems are being developed to improve the efficacy of oral antidiabetic medications.

Practitioners should consider new drug delivery methods to enhance treatment outcomes for T2DM.

The encapsulated oleogel-in-oleogel system has tailorable lipid digestion compared to conventional oleogels.

This system could be used to create food products with lower calorie content and customizable fat digestion profiles.

The encapsulated oleogel-in-oleogel system maintains the nanostructure of waxes and monoglyceride crystals.

Maintaining the nanostructure could enhance the functional properties of food products using this system.

The digestibility of the encapsulated oleogel-in-oleogel system can be modulated by varying the ratio of its components.

This flexibility allows for the design of food products tailored to specific dietary needs.

Non-esterified fatty acids (NEFA) increase negative charge of LDL and decrease its processing by 'normal' receptors while increasing processing by 'scavenger' receptors.

This knowledge can guide interventions targeting LDL metabolism in clinical nutrition.

GIPR activation influences energy balance and insulin sensitivity through mechanisms involving metabolic and thermogenic genes.

Understanding the molecular mechanisms of GIPR could inform strategies for improving insulin sensitivity.

New pharmacological molecules are likely to be treatment options for patients with rare genetic obesities in the coming years.

Practitioners should stay informed about emerging pharmacological treatments for obesity.

The positioning of new therapeutics in the management of rare genetic obesities needs to be well defined.

Clinicians should consider how to integrate new therapeutics into treatment plans for obesity.

Phosphocreatine (PCr) resynthesis is not associated with greater physical fitness (VO2 peak) or mRNA levels of mitochondrial function markers.

Improving physical fitness may not directly influence muscle recovery rates as measured by PCr resynthesis.

Polymeric biomaterials have gained tremendous interest for their potential in the prevention and treatment of obesity.

Practitioners should consider polymeric biomaterials as a promising avenue for obesity treatment.

Recent studies have identified new genetic regulatory mechanisms and potential biomarker regions for the POMC gene and MC4R secondary messenger pathway associated with obesity.

These findings may lead to new diagnostic tools for obesity.

The compounds K2 and K5 modify CCK1 activity by preventing/hindering interactions between CCK peptides and CCK1.

Understanding how K2 and K5 interact with CCK1 can guide drug development.

Increased consumption of whole grains compared to refined grains independent of weight loss had no effect on blood pressure, CRP levels, and most other risk factors for cardiovascular disease.

Practitioners should note that increasing whole grain intake alone may not improve cardiovascular risk factors without weight loss.

Sequence variation in at least six genes is linked to increased body fatness and/or susceptibility to obesity in humans.

Genetic testing may help identify individuals at higher risk for obesity.

Five genes are linked to disproportionate fat storage in the abdominal region.

Understanding genetic predispositions can inform strategies for managing abdominal obesity.

An indirect effect of T2DM on less improvement in verbal memory was mediated by monohexylceramide C16 : 1.

Interventions aimed at improving memory in T2DM patients may need to consider sphingolipid levels.

An indirect effect of T2DM on less visuospatial memory improvement was mediated by ceramide C22 : 0 concentrations.

Practitioners should monitor ceramide levels when addressing visuospatial memory in T2DM patients.

Recent studies support the plausibility and evidence of individual nutritional measures for dyslipidemias.

Practitioners should stay updated on recent studies regarding nutritional interventions for dyslipidemias.

Exercise may improve glycemic control through key cellular and molecular adaptive processes.

Practitioners should consider the types of exercise that promote these adaptive processes for better glycemic control.

Stacking some supplements may provide additional benefits, but can also lead to unintentional ingredient doubling.

Athletes should be cautious about stacking to avoid negative interactions.

Mendelian randomisation awaits confirmation with RCT and real-world data.

Further research is needed to confirm the findings regarding GLP-1RA and suicide attempts.

Impaired vitamin K2-dependent processes by some types of vegetable oils and medicines are proposed as a cause of cardiovascular disease, diabetes, and other lifestyle-related diseases.

Consideration of vitamin K2 status may be important in managing cardiovascular and metabolic health.

Adiponectin activates AMPK, a putative master metabolic regulator.

Understanding the role of AMPK activation could inform therapeutic strategies targeting metabolic disorders.