Browse the evidence

QRISK decreased markedly after weight loss from 18.9 ± 2.2% to 11.2 ± 1.6%, p < 0.0001.

Weight loss can significantly reduce cardiovascular risk in individuals with T2DM.

Normalization of 10-year cardiovascular risk and heart age is possible after substantial dietary weight loss and remission of T2DM.

Achieving weight loss and diabetes remission can significantly improve long-term cardiovascular health outcomes.

Practical interventions focused on dietary protein manipulation are proposed to prevent the onset of anabolic resistance.

Implementing dietary changes can be a proactive approach to combat age-related muscle loss.

ω-3-PL/FFA reduced triglyceride (TG) levels by 26.0% at 12 weeks compared to 15.1% in the placebo group.

Practitioners can consider ω-3-PL/FFA as an effective option for lowering TG levels in patients with severe hypertriglyceridemia.

Recently developed therapeutics may enable effective management of body weight in patients with obesity.

Healthcare providers may consider new therapeutics for obesity management.

Leucine-enriched protein supplementation enhances anabolic protein signaling compared to rest.

Supplementing with leucine can improve anabolic signaling during resistance training.

Fifteen participants displayed robust benefits of moderate-volume training on muscle hypertrophy, associated with greater total RNA accumulation.

Identifying individuals who respond well to moderate training volume can help tailor training programs for better hypertrophy outcomes.

Adopting MLCDs, particularly those with sufficient fiber content, can reduce the risk of cardiovascular diseases in patients suffering from dyslipidemia.

Practitioners may consider recommending MLCDs with sufficient fiber to patients with dyslipidemia to help reduce cardiovascular risks.

Unhealthy eating can contribute to various diseases, while healthy eating can positively influence or even reverse some of those diseases.

Practitioners should emphasize the importance of healthy eating in disease prevention and management.

Personalized nutrition (PN) interventions can improve eating behavior with potential to improve health.

Practitioners should consider implementing personalized nutrition strategies to enhance dietary adherence and health outcomes.

Addressing insulin resistance is important in the management of T2DM.

Clinicians should prioritize addressing insulin resistance in T2DM treatment plans.

Different sources of dietary protein and non-protein nutrients like omega-3 fatty acids regulate muscle protein synthesis.

Incorporating diverse protein sources and omega-3s may enhance muscle protein synthesis.

Markers of inflammation decreased, and gut microbiota exhibited increased metagenomic richness (P < .05) following the exercise program.

Improving gut microbiota and reducing inflammation may enhance overall health in NAFLD patients through exercise.

AM833 is a novel nonselective agonist of calcitonin family receptors that has demonstrated efficacy for the treatment of obesity in phase 2 clinical trials.

AM833 may be a promising treatment option for obesity management.

Higher levels of linoleic acid (LA) were significantly associated with lower risks of total cardiovascular disease (CVD) with a hazard ratio of 0.93 (95% CI, 0.88-0.99).

Increasing dietary intake of linoleic acid may help reduce the risk of cardiovascular disease.

Higher levels of linoleic acid (LA) were associated with lower cardiovascular mortality with a hazard ratio of 0.78 (95% CI, 0.70-0.85).

Higher linoleic acid intake may contribute to reduced cardiovascular mortality.

The diet beneficially altered microbiota-derived plasma metabolites implicated in chronic non-communicable diseases.

Practitioners may consider the impact of dietary choices on metabolites that influence chronic disease risk.

Non-alcoholic fatty liver disease (NAFLD) increases the risk of incident type 2 diabetes (T2D).

Practitioners should monitor T2D risk in patients with NAFLD.

Resmetirom has shown positive effects regarding CVD risk in the context of MASLD treatment.

Consider resmetirom as a potential treatment option for patients with MASLD at risk for CVD.

Protein-polyphenol drink ingestion likely accelerates recovery of muscle function by attenuating inflammatory NF-κB transcriptional signaling.

Incorporating protein-polyphenol drinks may enhance recovery from muscle damage.

Protein-polyphenol drinks decreased muscle IL1R1 and IL1RL1 messenger RNA expression compared to the placebo.

Using protein-polyphenol drinks may help modulate inflammatory responses post-exercise.

The reductions in TG levels persisted at 26 weeks with a mean treatment difference of -12.7% compared to placebo.

ω-3-PL/FFA may provide long-term benefits in managing TG levels.

Nitric oxide was significantly higher for high velocity resistance training (HVRT) compared to traditional resistance training (RT) after 30 minutes of exercise.

Practitioners may consider HVRT to enhance nitric oxide production in elderly hypertensive women.

N-3 PUFA had no added benefit on muscle protein synthesis (MPS) but showed a trend towards increased absolute synthesis rates (ASR) during weeks 4–6 of resistance exercise training.

While n-3 PUFA may not significantly enhance MPS, it could still support muscle adaptation during resistance training.