Browse the evidence

Practical interventions focused on dietary protein manipulation are proposed to prevent the onset of anabolic resistance.

Implementing dietary changes can be a proactive approach to combat age-related muscle loss.

ω-3-PL/FFA reduced triglyceride (TG) levels by 26.0% at 12 weeks compared to 15.1% in the placebo group.

Practitioners can consider ω-3-PL/FFA as an effective option for lowering TG levels in patients with severe hypertriglyceridemia.

Recently developed therapeutics may enable effective management of body weight in patients with obesity.

Healthcare providers may consider new therapeutics for obesity management.

Leucine-enriched protein supplementation enhances anabolic protein signaling compared to rest.

Supplementing with leucine can improve anabolic signaling during resistance training.

Adopting MLCDs, particularly those with sufficient fiber content, can reduce the risk of cardiovascular diseases in patients suffering from dyslipidemia.

Practitioners may consider recommending MLCDs with sufficient fiber to patients with dyslipidemia to help reduce cardiovascular risks.

Unhealthy eating can contribute to various diseases, while healthy eating can positively influence or even reverse some of those diseases.

Practitioners should emphasize the importance of healthy eating in disease prevention and management.

Personalized nutrition (PN) interventions can improve eating behavior with potential to improve health.

Practitioners should consider implementing personalized nutrition strategies to enhance dietary adherence and health outcomes.

The diet beneficially altered microbiota-derived plasma metabolites implicated in chronic non-communicable diseases.

Practitioners may consider the impact of dietary choices on metabolites that influence chronic disease risk.

Non-alcoholic fatty liver disease (NAFLD) increases the risk of incident type 2 diabetes (T2D).

Practitioners should monitor T2D risk in patients with NAFLD.

Resmetirom has shown positive effects regarding CVD risk in the context of MASLD treatment.

Consider resmetirom as a potential treatment option for patients with MASLD at risk for CVD.

The reductions in TG levels persisted at 26 weeks with a mean treatment difference of -12.7% compared to placebo.

ω-3-PL/FFA may provide long-term benefits in managing TG levels.

Tirzepatide was evaluated for its effects on cardiovascular and diabetic kidney disease biomarkers in overweight and obese adults with type 1 diabetes over a period of 21 months.

Practitioners may consider tirzepatide for managing cardiovascular and kidney health in overweight and obese patients with type 1 diabetes.

All exercise bouts increased mRNA expression of MYOD1 and MYF6 over time.

Engaging in exercise can enhance the expression of key myogenic factors involved in muscle growth.

Several of the observed protein associations were also linked to prevalent obesity in the Framingham Heart Study.

Understanding these associations may inform obesity prevention strategies.

CLA supplementation altered 57 metabolites enriched in lipids/lipid-like molecules compared to placebo.

CLA supplementation may lead to significant changes in lipid metabolism.

Long-acting GLP-1 pharmacological agents have been approved for the treatment of obesity.

Practitioners can consider long-acting GLP-1 agents as viable options for obesity management.

Macronutrients and micronutrients influence cardiovascular disease (CVD).

Nutritional recommendations for CVD prevention should include a focus on both macronutrients and micronutrients.

Obesity is linked to increased cancer susceptibility and adverse prognostic outcomes.

Awareness of obesity's impact on cancer outcomes is essential for patient management.

Coconut milk supplementation induced beneficial changes in the lipid profile, decreasing LDL and non-HDL levels while increasing HDL levels.

Incorporating coconut milk into the diet may improve lipid profiles, particularly for individuals with elevated LDL levels.

The subgroup with elevated baseline LDL levels benefited most from coconut milk supplementation.

Individuals with high LDL levels may see greater improvements in their lipid profiles by consuming coconut milk.

The MC4R rs17782313 polymorphism has positive effects on dietary glycemic index (GI) and glycemic load (GL) (B = 1.577; P ≤ 0.01 for GI; B = 1.235; P ≤ 0.01 for GL).

Understanding the genetic basis of GI and GL can inform dietary recommendations for obesity management.

Both IF and KD enhance insulin sensitivity, promote autophagy, reduce inflammation, and activate energy-regulating pathways (AMPK) while inhibiting mTOR.

Understanding these mechanisms can help practitioners explain the benefits of IF and KD to patients.

Higher ultraprocessed grain intake is associated with increased risk of developing inflammatory bowel disease (IBD), with participants consuming ≥19 g/d having a hazard ratio (HR) of 1.86 compared to those consuming <9 g/d.

Practitioners should advise minimizing ultraprocessed grain consumption to reduce IBD risk.

Participants with greater ultraprocessed food intake (≥5 servings per day) are linked to a higher risk of developing IBD, with a hazard ratio of 3.95 compared to those consuming <1 serving per day.

Reducing ultraprocessed food intake may lower the risk of IBD.