Browse the evidence

Protein supplementation during aerobic training did not significantly enhance cardiorespiratory fitness compared with an isocaloric placebo.

Practitioners should consider that protein supplementation may not provide additional benefits for improving cardiorespiratory fitness in stroke patients undergoing aerobic training.

Resistance training intensity was less than 40% of 1 repetition maximum in both young and older adults.

Practitioners should be aware that low-load resistance training may not effectively increase muscle strength and mass.

The low-intensity resistance training program may be insufficient for increasing muscle strength and mass among both young and older adults.

Low-intensity resistance training may not be adequate for rehabilitation goals related to muscle strength.

Supplementation often fails to improve protein balance or related physiological and performance outcomes under severe operational stress.

Practitioners should consider that protein supplementation may not be beneficial in high-stress operational environments.

There was no significant relationship between body fat mass changes and daily protein intake.

Practitioners should note that increasing protein intake may not affect body fat loss in older women.

Twenty percent of survey respondents had a high overall score on the Eating Attitudes Test (EAT-26), indicating high rates of disordered eating behaviors.

Practitioners should be aware of the prevalence of disordered eating in this population when addressing weight loss.

All interview participants reported engaging in and/or observing disordered eating behaviors in efforts to lose weight.

Understanding the social dynamics of disordered eating can inform interventions.

Disordered eating behaviors produced ripples of embodied experiences affecting family, friends, and coworkers of dieters.

Practitioners should consider the social context of disordered eating when developing support strategies.

Concerns exist regarding the cardiovascular safety of diets, particularly related to weight fluctuations and ketogenic diets.

Practitioners should be cautious about the cardiovascular implications of certain diets.

There is currently no definitive evidence that carbohydrate reduction per se durably lowers glycaemia in type 2 diabetes.

Caution against assuming that reducing carbohydrates will always improve glycaemic control.

Medication adherence increased from 52.8% to 84%.

Encouraging medication adherence can significantly improve patient outcomes.

Pre-intervention, the score of the survey of adherence to the Mediterranean diet was relatively low (7.44 ± 0.22 points).

Understanding baseline adherence levels can help tailor interventions effectively.

In women, an ILI-associated decrease in estradiol of 14% from baseline to year 1 mediated a decline in whole-body BMD of -1.15 mg/cm2.

Practitioners should consider the hormonal changes in postmenopausal women when implementing weight loss interventions.

In men, an ILI-associated increase of 11% in total testosterone mediated a decline of hip BMD of -1.18 mg/cm2.

Practitioners should consider the hormonal changes in older men when implementing weight loss interventions.

ILI-associated changes in estradiol and total testosterone resulted in whole-body and hip bone loss.

Weight loss interventions may lead to hormonal changes that affect bone health in older adults.

The concept of diabesity is based on the twin epidemics of obesity and diabetes.

Healthcare providers should understand the link between obesity and diabetes in managing diabesity.

Lipotoxicity and inflammation cause insulin resistance in the liver and muscle.

Understanding these mechanisms can aid in developing treatment strategies for insulin resistance.

The T2D prediction model achieves 95.27% ROC-AUC, with 88.48% sensitivity and 87.19% specificity.

The model can be effectively used for early detection of T2D in diverse populations.

The model handles missing data naturally without complex preprocessing and imputation.

The model's ability to manage incomplete data makes it suitable for real-world applications.

Insulin resistance in aging is a multisystem phenomenon reflecting declining metabolic adaptability rather than a simple glucose disorder.

Practitioners should consider insulin resistance as a complex, systemic issue in older patients, not just a glucose management problem.

Age-related insulin resistance arises from interconnected mechanisms, including inflammaging, cellular senescence, and mitochondrial dysfunction.

Understanding these interconnected mechanisms can help in developing targeted interventions for older adults.

Muscle metabolic quality, rather than adiposity alone, emerges as a key determinant of insulin sensitivity in older adults.

Emphasizing muscle quality in interventions may improve insulin sensitivity in older patients.

Innovative obesity therapies could transform long-term outcomes of preeclampsia.

Practitioners should stay informed about new obesity therapies that may improve long-term health outcomes for women with preeclampsia.

Modern research has identified various factors that modulate insulin resistance, indicating the need for targeted therapies.

Identifying modulating factors can help in developing personalized treatment strategies for insulin resistance.