Browse the evidence

Fixed-amount food vouchers are less effective per person in larger households, requiring higher dollar values to achieve the same dietary improvement as in smaller households.

If you manage a food assistance program, do not give a flat $20 voucher to a family of 8 and expect the same per-person dietary benefit as for a single person. The subsidy is diluted. To help larger families achieve similar health outcomes, you must either increase the total dollar amount or provide additional non-financial support to help them navigate purchasing for more people.

SGLT2 inhibitors provide modest but sustained weight loss and blood pressure reduction, and synergize with other anti-obesity medications.

SGLT2 inhibitors offer modest weight and blood pressure benefits. They are best used in combination with other treatments (like GLP-1 RAs) to synergize benefits, rather than as a standalone primary therapy for obesity-related hypertension.

Achieving short-term (2-year) diabetes remission in patients with obesity and type 2 diabetes is associated with significantly reduced long-term overall mortality and increased life expectancy, primarily driven by decreased cardiovascular mortality.

If you have obesity and type 2 diabetes, working towards diabetes remission (normal blood sugar without medication) is one of the most powerful things you can do for your long-term survival. This study shows that even if you only achieve remission for two years, it is linked to living longer and a significantly lower risk of dying from heart disease. You do not need to stay in remission forever to gain this longevity benefit, and you can achieve it through various means, including lifestyle changes, not just surgery.

Inorganic nitrate supplementation (316-860 mg/day) improves vascular function and lowers blood pressure in older adults, which may indirectly support skeletal muscle health by enhancing nutrient delivery.

Older adults can improve blood pressure and vascular health by consuming inorganic nitrate (e.g., from beetroot juice) at doses of 316-860 mg per day. This may help deliver more nutrients to muscles, though direct muscle-building effects are not yet fully proven.

Higher consumption of ultra-processed foods (UPFs) is associated with an increased risk of developing type 2 diabetes mellitus (T2DM), with hazard ratios typically ranging from 1.12 to 1.53 for incremental increases in UPF intake.

Limit your intake of ultra-processed foods, particularly those high in added sugars, saturated fats, and specific additives like emulsifiers (e.g., carrageenan) or containing endocrine disruptors from packaging (e.g., BPA). Focus on reducing sugary beverages and processed meats, as these show the strongest link to T2DM risk, while noting that some processed items like whole grain breads may not carry the same risk.

Skeletal muscle hypertrophy following resistance training is associated with distinct, cell-type-specific non-coding RNA (ncRNA) expression patterns, including MYREM (myonuclear), MEG3 (satellite cells), and CARMN (linear association with lean mass gain), which mediate growth via discrete functional pathways rather than uniform bulk tissue changes.

Resistance training works for most people (61% in this large multi-study analysis). If you are not seeing expected gains, it may not be that you 'can't grow,' but that your body uses different molecular switches (ncRNAs) than the average responder. Focus on consistent, supervised resistance training; individual molecular responses vary, but the mechanical stimulus is the primary driver. Do not use 'non-response' as an excuse to stop training, as measurement error often masks small gains.

A one-week complete cessation from resistance training (deload) at the midpoint of a 9-week program does not enhance hypertrophy, power, or local muscular endurance compared to continuous training, and results in inferior strength gains.

If your goal is maximizing strength, do not take a full week off from resistance training. Continuous training yields better strength gains than a one-week complete break. If you take a break for hypertrophy, expect no loss in muscle size, but do not expect any extra growth. Use deloads to manage fatigue, not to force adaptation.

Back squat training elicits greater improvements in lower limb dynamic strength on a nonspecific strength test (45° leg press) compared to front squat training in recreationally trained females, while both variations produce similar hypertrophic adaptations in the lateral thigh.

If your goal is maximum strength, prioritize the back squat. It allows you to lift heavier loads, which translates to better strength gains on other exercises like the leg press. If your goal is just muscle growth in the quads, either squat works equally well, so choose the one you can perform with better technique and less joint pain. You do not need to force yourself to do front squats if they cause shoulder discomfort; the back squat will get you the same muscle growth.

Supplementation with 5g/day of 2'-fucosyllactose (2'-FL) for 6 weeks increases Bifidobacterium abundance in older adults, which is associated with elevated HDL cholesterol, fasting insulin, and FGF21 levels.

If you are an older adult, consuming 5 grams of 2'-fucosyllactose daily for 6 weeks may boost beneficial gut bacteria (Bifidobacterium) and improve metabolic markers like HDL cholesterol and insulin levels. This suggests that prebiotics designed for infants might offer health benefits for aging adults by modulating the gut microbiome.

The metabolic benefits of 2'-fucosyllactose (increased HDL, insulin, FGF21) are contingent on the subject being a 'responder' who experiences a bloom in Bifidobacterium abundance.

Not everyone will benefit from 2'-fucosyllactose. If you don't have Bifidobacterium in your gut, you might not see the metabolic improvements (like better HDL or insulin sensitivity) that others do. Testing your microbiome might help predict if this supplement is right for you.

Adapting bariatric surgery nutritional monitoring protocols (baseline screening, supplementation, periodic testing) to GLP-1RA therapy is recommended to mitigate long-term complications.

Ask your doctor for baseline blood tests for Vitamin D, B12, Iron, Calcium, and Magnesium before or shortly after starting GLP-1 therapy. Repeat these tests annually. Based on results, take a high-quality multivitamin and specific supplements as recommended. This is a proactive step to protect your long-term health.

Short-term intensive insulin therapy (IIT) can improve beta-cell function and induce remission in newly diagnosed Type 2 Diabetes patients.

If you are newly diagnosed, a short course of intensive insulin (2-4 weeks) can 'rest' your pancreas, potentially leading to remission. This is a strategic use of insulin to restore function, not a permanent commitment.

Tirzepatide should be used in combination with CPAP for patients with severe OSA, as the drug takes 6-12 months to significantly reduce AHI, leaving patients at risk during the interim.

If you have severe OSA, do not stop CPAP when starting tirzepatide. The drug takes 6-12 months to significantly reduce your apnea. Use CPAP nightly during this period to protect your heart and safety. After a year, if your AHI has dropped significantly, you and your doctor can discuss tapering off CPAP.

Sarcopenic obesity is a distinct clinical phenotype characterized by high fat mass and low skeletal muscle mass/function, associated with increased risks of frailty, mortality, and metabolic complications, requiring specific diagnostic algorithms (e.g., ESPEN-EASO) for identification.

If you have obesity and are experiencing weakness, fatigue, or functional decline, especially as you age, ask your doctor about sarcopenic obesity. It is not just 'being overweight'; it involves muscle loss which increases health risks. Diagnosis requires specific tests for muscle mass and strength, not just BMI.

The same 25g whey + 5g collagen blend increases myofibrillar protein synthesis during exercise recovery, but does NOT significantly increase muscle connective protein synthesis in the exercised leg compared to placebo.

If you are doing resistance training, your body already significantly boosts connective tissue synthesis. Adding a whey-collagen blend won't necessarily boost connective tissue synthesis further in the working muscles compared to just placebo, though it does help muscle protein synthesis. Focus on the blend for muscle growth, but don't expect it to be a magic bullet for tendon repair in exercised muscles.

Time since Type 2 Diabetes diagnosis is a significant moderator of absolute peak oxygen uptake, with longer duration associated with greater reductions in fitness.

The longer you have Type 2 Diabetes, the more your maximum oxygen uptake tends to drop. However, this decline is gradual. Prioritize exercise early in your diagnosis to preserve fitness, as the most significant drops may occur within the first 5 years.

A low-glycemic index (GI) diet is non-inferior to a whole-grain wheat-fiber diet in preventing arterial wall damage (measured by carotid vessel wall volume) over 3 years in patients with type 2 diabetes.

For people with type 2 diabetes, choosing a low-GI diet (emphasizing lentils, beans, and specific whole grains) is just as effective as a high-wheat-fiber diet for protecting arterial walls over the long term. While the wheat-fiber diet showed a significant increase in arterial wall volume in this study, the low-GI diet did not, suggesting it is a viable and effective strategy for cardiovascular risk reduction.

A low-GI diet preserves renal function (eGFR) better than a whole-grain wheat-fiber diet in patients with type 2 diabetes over 3 years.

If you have type 2 diabetes, a low-GI diet may offer better protection for your kidneys than a standard high-wheat-fiber diet. While both diets are healthy, the low-GI approach helped maintain kidney function (eGFR) better than the wheat-fiber diet, which showed a slight decline in kidney function over 3 years.

Metabolic surgery can reverse or significantly improve existing diabetic microvascular complications, including nephropathy, neuropathy, and retinopathy, independent of the degree of weight loss or glycemic control.

If you have Type 2 Diabetes and are developing kidney or nerve damage, metabolic surgery may offer benefits that standard blood sugar management cannot, potentially reversing or halting this organ damage.

Metabolic surgery is an effective treatment for Non-Alcoholic Steatohepatitis (NASH), significantly reducing liver steatosis, inflammation, and fibrosis, and reducing progression to hepatocellular carcinoma (HCC).

If you have NASH, metabolic surgery is currently the most effective treatment to reverse liver damage and reduce the risk of liver cancer, as current medications and lifestyle changes are largely ineffective.

Metabolic surgery reduces overall and cardiovascular mortality in patients with Type 2 Diabetes and obesity, independent of preoperative BMI.

Metabolic surgery significantly lowers the risk of death from heart disease and other causes in people with Type 2 Diabetes and obesity, offering a survival benefit that intensive medical management does not provide.

Alternative forms of creatine (e.g., creatine HCl, creatine ethyl ester, creatine malate) are not superior to creatine monohydrate (CM) in increasing muscle creatine content or improving exercise performance, despite marketing claims suggesting otherwise.

If you are buying creatine, stick to creatine monohydrate (CM). Alternative forms like creatine HCl, ethyl ester, or malate are marketed as superior, but scientific evidence shows they are not better at increasing muscle creatine or improving performance than standard CM. You are likely paying significantly more (up to 116% higher per gram) for no additional benefit.

GLP-1 receptor agonist-mediated weight loss causes facial volume loss and skin laxity that mimics advanced aging, a phenomenon termed 'Ozempic face,' which is managed through volume restoration (fillers/fat grafting) or skin tightening procedures.

If you are using GLP-1 medications like Ozempic or Wegovy, be aware that rapid weight loss can lead to facial volume loss and skin laxity, making you look older. This is a known side effect of the weight loss itself, not necessarily a unique drug effect on facial fat. You can manage this with fillers, fat grafting, or skin tightening procedures. Discuss these risks with your provider before starting treatment.

Discontinuation of GLP-1 receptor agonists leads to significant weight regain (up to two-thirds of lost weight) and reversal of cardiometabolic improvements.

If you stop taking GLP-1 medications, you are likely to regain a significant portion of the weight you lost. Long-term use is often necessary to maintain weight loss and metabolic benefits. Discuss a long-term plan with your provider before stopping.