Browse the evidence

Bariatric surgery offers glycemic improvements and potential remission of early onset diabetes, but weight loss results are lower in patients with diabetes compared to those without.

Practitioners should be aware that while bariatric surgery can improve glycemic control, the weight loss outcomes may not be as significant for patients with diabetes.

Fifty-six studies reported statistically significant findings in outcome measures.

Interventions can lead to measurable improvements in health outcomes.

High overall or unhealthful low-fat diet (LFD) scores are associated with increased likelihood of steatosis (OR = 1.65 for overall LFD, OR = 1.41 for unhealthful LFD).

Avoiding high scores in unhealthful low-fat diets may reduce the risk of hepatic steatosis.

MyoPS rates were comparable between resistance-only exercise and concurrent exercise groups before and after training.

Both resistance-only and concurrent exercise can effectively promote muscle protein synthesis in moderately active individuals.

Concurrent exercise did not compromise the anabolic response to resistance-only exercise, before or after training.

Practitioners can incorporate concurrent exercise without fear of diminishing the benefits of resistance training.

Using LNCSBs as a substitute for SSBs was associated with small improvements in cardiometabolic risk factors without evidence of harm.

Practitioners can consider LNCSBs as a safe alternative to SSBs for improving health outcomes.

Protein interacts with carbohydrates, fats, and dietary energy density to influence calorie intake and metabolic physiology.

Understanding protein's role can help in designing effective dietary interventions.

Considering interactions among dietary components can help reconcile different models of obesity.

Practitioners should consider dietary interactions when developing obesity interventions.

The intervention achieved 100% attendance and adherence to self-monitoring.

Practitioners can implement remote monitoring strategies to enhance adherence in older adults.

Reductions in fat mass were similar across all protein intake groups, with LP, MP, and HP showing reductions of 1.7%, 3.7%, and 3.1% respectively (P > 0.05).

Fat loss outcomes may not significantly differ based on protein intake levels in older women undergoing resistance training.

Tirzepatide achieved similar 12-month TBWL% as R-ESG (13.2% vs. 13.4%, p = .9) and significantly more than semaglutide (13.2% vs. 8.1%, p = .04).

Tirzepatide may be a viable alternative for weight loss in patients post-sleeve gastrectomy, potentially outperforming semaglutide.

Both FDA-approved gastric balloon systems (gas-filled IGB and fluid-filled IGB) had the same effectiveness in terms of percent total body weight loss at balloon removal.

Both balloon systems can be considered equally effective for weight loss.

The gas-filled IGB had fewer serious adverse events and better tolerability than the fluid-filled IGB.

The gas-filled IGB may be a safer option for patients.

The implementation of a pharmacist-led weight management clinic resulted in an estimated cost savings of $101,985.66.

Pharmacist involvement can lead to significant cost savings in weight management programs.

Females tended to lose more weight (Mean = 9.75) than males (Mean = 8.41).

Practitioners may consider gender differences when designing weight-loss interventions.

The semaglutide group mostly showed higher RSFC after the intervention, while the placebo group mostly showed lower RSFC in a selection of investigated ROIs.

This suggests that semaglutide may influence RSFC positively, but the clinical significance remains uncertain.

Discontinuation rates were strongly associated with copayment amount, increasing from 41% in the lowest quintile to 51% in the highest quintile.

Financial considerations significantly impact patient adherence to semaglutide treatment.

Minimally invasive bariatric surgeries, endoscopic procedures, fecal microbiota transplants (FMTs), and pharmaceuticals like GLP-1 receptor agonists show promising results for obesity treatment.

Practitioners should consider these innovative treatment options for obesity management.

Diabetes management is being transformed by continuous glucose monitoring (CGM) systems and closed-loop insulin delivery.

Healthcare providers should adopt CGM systems and closed-loop delivery for improved diabetes management.

Bariatric surgery is the most cost-effective definitive treatment for all classes of obesity.

Healthcare systems should prioritize bariatric surgery as a treatment option for obesity.

Participants enrolling during program periods with access to a larger number of stores had ≤14.5% absolute higher redemption rates and 5-fold greater likelihood of shopping each month than those enrolled with fewest locations.

Increasing the number of stores available for produce prescription programs may enhance redemption rates and shopping frequency.

Redemption rates increased over time for participants in the program, rising from 31% in month 1 to 88% in month 24.

Longer participation in produce prescription programs is associated with significantly higher redemption rates.

Effects on gastric emptying appeared additive when BI 1820237 was combined with low-dose liraglutide.

Combining BI 1820237 with liraglutide may enhance effects on gastric emptying, which could be relevant for treatment strategies.

Some people with HIV treated with antiretroviral therapy gain unhealthy amounts of weight and develop consequences of obesity.

Healthcare providers should monitor weight changes in PWH on ART.