Browse the evidence

GLP-1RA users had a lower risk of all-cause mortality (HR, 0.70; 95% CI, 0.63-0.78) compared to other antidiabetic drug users.

Practitioners may consider GLP-1RAs as a treatment option for reducing all-cause mortality in this population.

ATP supplementation has been reported to result in positive effects on muscle mass, strength, and power gains.

ATP supplementation may be beneficial for enhancing muscle performance metrics.

Obesity is a leading risk factor for cardiovascular disease (CVD).

Clinicians should prioritize addressing obesity to mitigate CVD risks.

Multidomain lifestyle intervention may slow biological aging long term, as captured by an FI-E.

Practitioners may consider recommending multidomain lifestyle interventions to promote long-term health benefits.

The relative effectiveness of intensive lifestyle intervention (ILI) on cardiovascular disease (CVD) incidence is inversely related to baseline frailty index (FI) in a graded fashion.

Practitioners should consider the frailty status of patients when recommending lifestyle interventions for CVD risk reduction.

Individuals in the first tertile of frailty index experienced a relative benefit from ILI with a hazard ratio of 0.73.

Less frail individuals may benefit more from intensive lifestyle interventions for CVD risk reduction.

Nutrient availability plays an important role in modulating many of the adaptive responses to endurance training.

Practitioners should consider nutrient timing and availability to enhance endurance training adaptations.

Nutrient-exercise interventions can modulate contraction-induced responses in muscle.

Nutrient timing and composition should be tailored to enhance muscle responses during training.

Both FAST and SLOW repetition tempos produced similar increases in muscle thickness at the proximal portion of the quadriceps.

Practitioners can use either tempo for muscle thickness gains in trained individuals.

A single bout of strenuous exercise prevents the attenuation of muscle protein synthesis (MPS) response to protein ingestion caused by high-circulating lipid availability.

Incorporating strenuous exercise may enhance the effectiveness of protein intake in individuals with high lipid levels.

Exercise enhances the efficiency of skeletal muscle to utilize amino acid substrate for the postprandial anabolic response.

Exercise may improve the anabolic response to protein intake, suggesting a potential strategy for enhancing muscle growth.

Upper limb lean soft tissue changes were statistically similar between both training conditions, with increases of +5.2% for MJ-SJ and +7.5% for SJ-MJ.

Both exercise orders can be effective for increasing upper limb lean mass.

Physical activity and exercise training modify the biological effects of accelerated aging considerably.

Incorporating regular physical activity and exercise can significantly mitigate the effects of aging on cardiovascular health.

All-cause mortality rate was 30% lower per SD greater METs (hazard ratio (HR) = 0.70; rate difference (RD), -2.71 deaths/1000 person-years).

Improving cardiorespiratory fitness can significantly lower mortality risk in individuals with type 2 diabetes.

An SD greater METs predicted lower cardiovascular disease mortality (HR, 0.45; RD, -1.65 cases/1000 person-years).

Increasing cardiorespiratory fitness can reduce the risk of cardiovascular disease mortality in individuals with type 2 diabetes.

Greater CRF is associated with reduced risks of mortality and cardiovascular disease events.

Enhancing cardiorespiratory fitness is crucial for lowering mortality and cardiovascular disease risks in this population.

Some patients with type 2 diabetes can experience sustained metabolic improvement to near-normal levels of glycemia, recognized as remission of diabetes.

Practitioners should recognize the potential for remission in T2DM patients.

Obesity increases stress throughout the musculoskeletal system and carries a higher risk for the development of osteoarthritis and various other musculoskeletal conditions.

Healthcare providers should consider the musculoskeletal risks associated with obesity when treating patients.

Obesity is associated with increased risk of complications in patients undergoing total joint arthroplasty.

Surgeons should be aware of the increased risks when treating obese patients in joint surgeries.

A high body mass index is one of the strongest risk factors for new-onset chronic kidney disease.

Monitoring BMI can be crucial for preventing chronic kidney disease.

The presence of NAFLD is associated with severe liver complications and increased mortality from cardiovascular disease.

Primary care providers should monitor cardiovascular health in patients with NAFLD.

The deuterated water method allows for the assessment of muscle tissue protein synthesis rates under free-living conditions.

This method can be used to measure protein synthesis in everyday life, enhancing research relevance.

The use of anti-obesity medications in patients with heart failure may improve functional status, biomarkers of inflammation, and heart failure stability.

Anti-obesity medications may not only aid in weight loss but also enhance overall heart failure management.

Recovery of isokinetic maximal voluntary contraction (MVC) at 90°·s−1 was faster in the carbohydrate group compared to the whey protein group.

Carbohydrate supplementation may be more effective than whey protein for recovery of isokinetic strength.