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Lifestyle recommendations for nutritional care and physical activity in diabetes management are poorly implemented.

Practitioners should enhance the implementation of lifestyle interventions in diabetes care.

The macrovascular benefits of GLP-1 receptor agonists should be prioritized over potential microvascular progression of DR.

Healthcare providers should weigh the cardiovascular benefits of GLP-1 receptor agonists against the risks of worsening DR.

GLP-1RA is underutilized due to cardiologists' unfamiliarity and hesitation.

Addressing these barriers could improve GLP-1RA utilization in clinical practice.

Endoscopic sleeve gastroplasty is a novel technique of endoscopic bariatric therapies that has shown safety, efficacy, and cost-effectiveness.

Practitioners can consider endoscopic sleeve gastroplasty as a viable option for patients who are not candidates for traditional bariatric surgery.

Semaglutide treatment following catheter ablation for atrial fibrillation is associated with a lower rate of atrial arrhythmia recurrence over 12 months (hazard ratio, 0.68; P =0.030).

Practitioners may consider semaglutide as a therapeutic option to reduce atrial arrhythmia recurrence post-ablation.

Semaglutide treatment led to larger reductions in glycated hemoglobin levels compared to the control group (−1.3% vs. −0.6%; P <0.001).

Semaglutide may improve glycemic control in patients post-ablation.

Multidisciplinary combined therapy enhances the long-term efficacy of bariatric surgery.

Incorporating multidisciplinary approaches can improve patient outcomes post-surgery.

Caloric reduction may exacerbate nutrient inadequacies among adults with overweight or obesity.

Practitioners should consider the potential for nutrient deficiencies when advising caloric restriction for weight loss.

After a simulated 30% caloric reduction, 25%–40% of the population had intakes below the EAR for protein, vitamin B-6, and zinc.

Practitioners should monitor specific nutrient intakes when implementing caloric reductions.

Long-acting GLP-1 pharmacological agents have been approved for the treatment of obesity.

Practitioners can consider long-acting GLP-1 agents as viable options for obesity management.

Body mass index is associated with all-cause and cardiovascular disease mortality in both men and women.

BMI should be considered a critical factor in assessing mortality risk.

Macronutrients and micronutrients influence cardiovascular disease (CVD).

Nutritional recommendations for CVD prevention should include a focus on both macronutrients and micronutrients.

In men, a 14.4% ILI-associated increase in total testosterone at year 1 mediated increases in weight (189 g; 95% CI, 65-317) and waist circumference (0.135 cm; 95% CI, 0.19-0.248) at year 4.

Practitioners should consider the role of testosterone in managing weight and waist circumference in men with type 2 diabetes.

In women, a 21.8% decrease in bioavailable testosterone at year 1 mediated decreases in whole-body fat mass (-164; 95% CI, -326 to -29.3), whole-body lean mass (-115 g; 95% CI, -203.4 to -40), and trunk lean mass (-97.2 g; 95% CI, -156 to -45.5) at year 4.

Practitioners should consider the role of bioavailable testosterone in managing body composition in women with type 2 diabetes.

The study revealed sex-specific mediating effects of sex hormones due to weight loss from intensive lifestyle intervention on body composition changes in people with type 2 diabetes.

Practitioners should tailor weight loss recommendations based on sex differences in hormone responses.

TGD patients frequently present to their endocrinologists for individualized, gender-affirming support to meet BMI cutoffs for GAS.

Endocrinologists should provide tailored support to help TGD patients achieve necessary BMI for GAS.

Multidisciplinary management considerations are offered for clinicians to assist TGD patients with obesity navigate BMI requirements to access GAS.

Clinicians should adopt a multidisciplinary approach to support TGD patients in meeting BMI requirements for GAS.

Participants improved their accuracy in estimating repetitions in reserve (RIR) during the bench press over the intervention.

Improving RIR estimation can enhance training effectiveness and safety.

Low-load resistance training may be more effective in producing type I muscle fibre hypertrophy, while high-load may be more effective in producing type II muscle fibre hypertrophy.

Consider varying load types based on desired muscle fiber hypertrophy outcomes.

Low-carbohydrate diets may not be any better than other popular diets in helping people keep weight off permanently.

Consider a variety of diet options for long-term weight maintenance.

Satellite cell activation was similar between groups in the untrained state but showed a trend toward greater increases with MIS after RET.

There may be potential benefits of multi-ingredient supplementation on satellite cell activation post-exercise.

Previous positive information about static stretching improved performance in the last set of exercise for the positively biased group.

Practitioners may consider the impact of positive expectancy on performance outcomes during strength-endurance training.

Static stretching did not significantly interfere with total number of repetitions or total volume of exercise.

Static stretching may not negatively impact overall strength-endurance performance metrics.

Cognitive outcome is not a limitation for the use of calorie restriction for health improvement.

Health practitioners can recommend CR without fear of adverse cognitive effects.