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Semaglutide (2.4 mg once weekly) resulted in weight loss of up to 13.9% after 68 weeks.

Semaglutide is a viable weight loss treatment for adults without diabetes.

GLP-1 receptor agonists and co-agonists are efficacious for weight loss with safety concerns predominantly gastrointestinal.

Practitioners should consider GLP-1 RAs for weight management, noting gastrointestinal side effects.

The sport nutrition education intervention (SNEI) increased sport nutrition knowledge in NCAA Division I baseball players.

Implementing SNEI can effectively enhance nutrition knowledge among athletes.

Fat mass (FM) decreased in the nutrition intervention group (NI) but not in the control group (C).

SNEI may be effective for reducing fat mass in athletes during off-season training.

The 5-10-5 shuttle times decreased significantly more in the nutrition intervention group (NI) compared to the control group (C).

SNEI may enhance agility performance in athletes during off-season training.

Resistance exercise and nutrition impact muscle protein synthesis (MPS) and muscle protein breakdown (MPB).

Practitioners should consider incorporating resistance exercise and proper nutrition to enhance muscle health.

High doses of protein in the range of 1.2-2.5 g/kg/d may be required in the ICU to optimize nutrition therapy and reduce mortality.

Healthcare professionals should consider administering higher protein doses to critically ill patients to improve outcomes.

Achieving protein goals the first week following admission to the ICU should take precedence over meeting energy goals.

Prioritize protein intake in the first week of ICU admission to enhance recovery.

Lifestyle and behavioral modification for obesity and/or PDWG in psychiatric populations is effective.

Encouraging lifestyle changes can be beneficial for patients experiencing PDWG.

The main treatment goal for Metabolic Syndrome is weight loss and a decrease in insulin resistance.

Practitioners should focus on weight loss and reducing insulin resistance in patients with Metabolic Syndrome.

Dietary patterns such as Mediterranean-style, DASH, low-carbohydrate, and low-fat diets can ameliorate insulin resistance and MetS.

Practitioners should consider these dietary patterns for improving insulin resistance in patients.

Long-term adherence to a healthy lifestyle is key in reducing the risk of CVD and diabetes mellitus.

Practitioners should encourage long-term healthy lifestyle changes to reduce chronic disease risk.

Resistance training performed to failure (RTF) showed a greater increase in muscle hypertrophy than resistance training not to failure (RTNF) with a standardized mean difference (SMD) of 0.75 (p = 0.005).

Practitioners may consider incorporating training to failure for enhanced muscle hypertrophy.

Among the 62 associations between diet and cardiometabolic disease (CMD), 10 foods, 3 beverages, and 12 nutrients had at least probable evidence of associations with coronary heart disease, stroke, and/or diabetes.

Dietary guidance can be informed by these associations to help reduce the risk of CMD.

Starting an exercise session with multi-joint (MJ) exercises leads to greater strength gains in MJ exercises compared to starting with single-joint (SJ) exercises (ES = 0.32; p = 0.034).

Practitioners should prioritize MJ exercises at the beginning of training sessions for optimal strength gains.

Starting an exercise session with single-joint (SJ) exercises leads to greater strength gains in SJ exercises compared to starting with multi-joint (MJ) exercises (ES = -0.58; p = 0.032).

Practitioners should consider starting with SJ exercises for optimal strength gains in those movements.

Three sets of resistance training (G3S) resulted in significantly higher strength changes compared to one set (G1S).

Practitioners should consider recommending three sets of resistance training for greater strength improvements in older women.

The percentage of body fat changes were higher for the three sets group (G3S) compared to the one set group (G1S).

For fat loss, three sets of resistance training may be more effective than one set in older women.

Both training groups (G1S and G3S) showed greater increases in skeletal muscle mass compared to the control group (CG).

Resistance training is effective for increasing skeletal muscle mass in older women.

Muscle failure promotes greater muscle hypertrophy in low-load resistance training compared to not reaching muscle failure.

Practitioners should emphasize reaching muscle failure in low-load resistance training to enhance muscle growth.

High-load resistance training with muscle failure results in significantly greater strength gains compared to low-load training.

For strength training, using heavier loads is more effective than lighter loads.

Comprehensive, evidenced-based behavioral counseling interventions in primary care are a recommended first-line approach for promoting healthy behaviors and preventing poor cardiovascular disease outcomes in adults with cardiovascular risk factors.

Health care professionals should implement behavioral counseling as a primary strategy for cardiovascular disease prevention.

Assisting patients to adopt and achieve their health promotion goals and arranging follow-up support are critical tenets of the 5A Model for behavior counseling in primary care.

Implementing the 5A Model can enhance the effectiveness of behavioral counseling.

The scientific statement presents evidence of effective behavioral intervention programs that are feasible for adoption in primary care settings for cardiovascular disease prevention and risk management.

Primary care settings can adopt these programs to improve cardiovascular health outcomes.