Browse the evidence

GLP-1 receptor agonists have been successfully used in the treatment of obesity and type 2 diabetes.

GLP-1 receptor agonists can be considered as a treatment option for patients with obesity and T2DM.

For trials with a mean BMI ≥35, LDL cholesterol decreased by 7 mg/dL on a low-carbohydrate diet.

Practitioners should note that low-carbohydrate diets may lower LDL cholesterol in individuals with high BMI.

Weight loss is associated with a protective effect on the risk of type 2 diabetes.

Weight loss may be beneficial for reducing the risk of type 2 diabetes in this demographic.

High total protein intake is associated with low CVD morbidity (RR 0.88, 95% CI 0.82-0.94).

Encouraging higher protein intake may reduce the risk of cardiovascular disease.

The treatment with GLP-1 RA resulted in a reduction in the risk of any cardiovascular event with a relative risk of 0.81.

The relative risk indicates a significant benefit of GLP-1 RA in reducing cardiovascular events.

All training protocols significantly increased one repetition maximum (1RM) values post-training, with no significant differences between protocols.

Practitioners can expect similar strength gains across different rest intervals when volume is equalized.

Quadriceps cross-sectional area (QCSA) increased significantly for all protocols post-training.

All training protocols can effectively promote muscle hypertrophy.

Greater volume load (VL) plays a primary role for hypertrophy, regardless of interset rest interval.

Emphasizing volume load in training can enhance muscle growth, irrespective of rest intervals.

Combined protein ingestion with resistance exercise stimulates MPS to a similar degree in prostate cancer patients on ADT and controls.

Combining protein intake with resistance exercise can effectively stimulate muscle protein synthesis in both ADT patients and healthy controls.

Foot positioning during calf training affects gastrocnemius muscle thickness, with FPO leading to an 8.4% increase in medial MT and FPI leading to a 9.1% increase in lateral MT after 9 weeks.

Trainers can optimize calf training by adjusting foot positioning to target specific muscle heads.

Significant differences in muscle thickness gains were observed between FPO and FPI conditions.

Understanding these differences can help in designing targeted training programs.

Positioning FPO potentiated increases in medial gastrocnemius head thickness, while FPI provided greater gains for the lateral gastrocnemius head.

Trainers can use specific foot positions to target desired muscle adaptations.

Interdisciplinary interventions are effective in promoting weight loss.

Practitioners should consider interdisciplinary approaches to facilitate weight loss.

Ongoing support of participants is key to maintaining weight loss results beyond initial study duration.

Practitioners should implement ongoing support strategies for participants.

Interdisciplinary interventions showed consistent results for weight loss but not for blood lipids, blood glucose, and blood pressure.

Practitioners should focus on weight loss outcomes when using interdisciplinary interventions.

Suboptimal diet was the leading cause of cardiometabolic mortality in 4 of 5 countries, with population-attributable fractions from 40.7% in Bangladesh to 56.9% in Pakistan.

Health policies should prioritize addressing dietary factors to reduce cardiometabolic mortality.

High fasting plasma glucose, low fruit intake, and low whole grain intake follow as significant causes of cardiometabolic mortality across all nations.

Encouraging higher intake of fruits and whole grains may help reduce cardiometabolic mortality.

Increasing physical activity after weight loss can effectively re-establish a state of high energy flux without significant weight regain.

Practitioners should encourage increased physical activity in clients who have lost weight to help maintain their weight loss.

The Hybrid behavioral weight loss program resulted in a weight loss of 4.8 ± 4.9 percent.

Practitioners may consider Hybrid programs to enhance weight loss outcomes in emerging adults.

The percent achieving ≥5 percent weight loss was highest in the Hybrid program (63%).

Practitioners should aim for strategies that help participants achieve significant weight loss in this age group.

Postexercise whole egg ingestion increases knee extension and handgrip strength, testosterone, and reduces body fat percentage compared with postexercise egg white ingestion.

Practitioners may consider recommending whole egg consumption post-exercise for improved strength and body composition.

There was a significant group × time interaction for body fat percentage, serum testosterone, knee extension, and handgrip strength with greater improvements observed in the whole egg group.

The results suggest that whole egg consumption may be more beneficial for strength and body composition improvements during resistance training.

Exercise training can be targeted as a treatment strategy in the prevention and treatment of insulin resistance.

Practitioners should consider exercise training as a key intervention for managing insulin resistance.

>10% weight loss is strongly associated with major macrovascular events (HR, 1.75; 95% CI, 1.26-2.44) in patients with type 2 diabetes.

>10% weight loss in patients with type 2 diabetes should prompt further cardiovascular risk assessment.