Browse the evidence

Major brand-name reformulations generally reduced the trans fat content substantially without making equivalent increases in saturated fat content.

Food manufacturers can reformulate products to lower trans fat without increasing saturated fat.

Different sources of dietary protein and non-protein nutrients like omega-3 fatty acids regulate muscle protein synthesis.

Incorporating diverse protein sources and omega-3s may enhance muscle protein synthesis.

Markers of inflammation decreased, and gut microbiota exhibited increased metagenomic richness (P < .05) following the exercise program.

Improving gut microbiota and reducing inflammation may enhance overall health in NAFLD patients through exercise.

Untargeted metabolite profiling identified biomarkers reflecting oxidative stress inhibition due to nutritional intervention.

Identifying these biomarkers can help in assessing the effectiveness of nutritional interventions.

Industrially-produced TFA can damage health.

Health professionals should inform patients about the risks of TFAs.

AM833 is a novel nonselective agonist of calcitonin family receptors that has demonstrated efficacy for the treatment of obesity in phase 2 clinical trials.

AM833 may be a promising treatment option for obesity management.

Higher levels of linoleic acid (LA) were significantly associated with lower risks of total cardiovascular disease (CVD) with a hazard ratio of 0.93 (95% CI, 0.88-0.99).

Increasing dietary intake of linoleic acid may help reduce the risk of cardiovascular disease.

Higher levels of linoleic acid (LA) were associated with lower cardiovascular mortality with a hazard ratio of 0.78 (95% CI, 0.70-0.85).

Higher linoleic acid intake may contribute to reduced cardiovascular mortality.

Caloric restriction can stimulate mitochondrial biogenesis and improve mitochondrial efficiency.

Implementing caloric restriction may enhance mitochondrial function and combat insulin resistance.

The diet beneficially altered microbiota-derived plasma metabolites implicated in chronic non-communicable diseases.

Practitioners may consider the impact of dietary choices on metabolites that influence chronic disease risk.

Non-alcoholic fatty liver disease (NAFLD) increases the risk of incident type 2 diabetes (T2D).

Practitioners should monitor T2D risk in patients with NAFLD.

Resmetirom has shown positive effects regarding CVD risk in the context of MASLD treatment.

Consider resmetirom as a potential treatment option for patients with MASLD at risk for CVD.

FAST lengthening contractions resulted in more Z-band streaming compared to SLOW contractions.

Incorporating FAST contractions may enhance muscle remodeling processes.

Endurance-trained males (ETM) had higher [3H]-ouabain binding and 3-O-MFPase activity than recreationally active males (RAM) by 16%.

Endurance training enhances Na+,K+-pump activity compared to recreational activity.

Protein-polyphenol drink ingestion likely accelerates recovery of muscle function by attenuating inflammatory NF-κB transcriptional signaling.

Incorporating protein-polyphenol drinks may enhance recovery from muscle damage.

Protein-polyphenol drinks decreased muscle IL1R1 and IL1RL1 messenger RNA expression compared to the placebo.

Using protein-polyphenol drinks may help modulate inflammatory responses post-exercise.

The reductions in TG levels persisted at 26 weeks with a mean treatment difference of -12.7% compared to placebo.

ω-3-PL/FFA may provide long-term benefits in managing TG levels.

Nitric oxide was significantly higher for high velocity resistance training (HVRT) compared to traditional resistance training (RT) after 30 minutes of exercise.

Practitioners may consider HVRT to enhance nitric oxide production in elderly hypertensive women.

N-3 PUFA had no added benefit on muscle protein synthesis (MPS) but showed a trend towards increased absolute synthesis rates (ASR) during weeks 4–6 of resistance exercise training.

While n-3 PUFA may not significantly enhance MPS, it could still support muscle adaptation during resistance training.

Tirzepatide was evaluated for its effects on cardiovascular and diabetic kidney disease biomarkers in overweight and obese adults with type 1 diabetes over a period of 21 months.

Practitioners may consider tirzepatide for managing cardiovascular and kidney health in overweight and obese patients with type 1 diabetes.

All exercise bouts increased mRNA expression of MYOD1 and MYF6 over time.

Engaging in exercise can enhance the expression of key myogenic factors involved in muscle growth.

Several of the observed protein associations were also linked to prevalent obesity in the Framingham Heart Study.

Understanding these associations may inform obesity prevention strategies.

CLA supplementation altered 57 metabolites enriched in lipids/lipid-like molecules compared to placebo.

CLA supplementation may lead to significant changes in lipid metabolism.

Fifteen distinct gene clusters are regulated by disuse and connected to muscle mass or MPS changes.

Understanding these gene clusters may help in developing interventions to mitigate muscle loss during disuse.