Browse the evidence

Interactions between the genetic risk score and dietary factors, specifically trans fats, were observed, indicating that the effects of trans fats on CHD risk are more pronounced in individuals with a higher genetic risk score.

Understanding the interaction between genetics and diet can help tailor dietary recommendations for individuals at higher genetic risk for CHD.

At average weight loss, the effect of a higher PS amounted to a change of 0.20-0.28 cm per standard deviation in WCadjBMI.

The small effect size suggests that genetic factors may have limited practical implications for weight loss interventions.

Plant-based diets improve cardiovascular health by modulating gut microbiota and metabolites.

Practitioners may consider recommending plant-based diets for cardiovascular health.

A stronger decline in sACE2 during the diet intervention was independently associated with improvements in metabolic health markers.

Improvements in metabolic health may be linked to changes in sACE2 levels during weight loss.

Early genetic diagnostics can identify the type of obesity and guide therapy options.

Implementing genetic testing can enhance personalized treatment strategies for obesity.

GLP-1 receptor agonists and dual incretin agonists provide clinically significant benefits in weight reduction, blood pressure modulation, lipid profile improvement, and cardiovascular risk mitigation.

Practitioners can consider GLP-1 receptor agonists and dual agonists as effective options for managing weight and cardiovascular health in patients with T2DM and obesity.

Bariatric surgery has a protective effect on type 2 diabetes incidence and cardiovascular risk factors in both eligible and non-eligible patients.

Bariatric surgery may be beneficial for a wider range of patients than currently eligible.

Consumption of ultra-processed foods (UPFs) is associated with increased cardiovascular (CV) risk.

Clinicians should consider the impact of UPFs when advising patients on cardiovascular health.

Excessive carbohydrate intake has noxious effects on human health, referred to as 'carbotoxicity.'

Practitioners should consider the negative health impacts of excessive carbohydrate consumption.

Reducing carbohydrate intake has beneficial effects on health.

Reducing carbohydrate intake may improve health outcomes.

Excess adiposity is the main phenotypic feature that defines human obesity and plays a pathophysiological role in most chronic diseases.

Understanding the role of excess adiposity can guide interventions for obesity and related chronic diseases.

Improving insulin sensitivity is anticipated to lower plasma glucose concentration and decrease CVD risk in T2DM patients, independent of glucose control.

Enhancing insulin sensitivity can be a key strategy in T2DM management.

Modified probiotic strains and supraphysiological dosages of microbial metabolites may be beneficial in combatting obesity.

Consider using modified probiotics and microbial metabolites in obesity treatment strategies.

Cherries have antioxidant and anti-inflammatory properties.

Including cherries in the diet may help reduce oxidative stress and inflammation.

Defined diets have been tested as preventive and treatment approaches for diseases such as epilepsy, ulcerative colitis, Crohn disease, and type 1 diabetes mellitus.

Defined diets may be considered in clinical settings for managing specific diseases.

Yoga intervention for 10 weeks significantly reduced DNA damage indicators in T2D subjects, including Tail Moment (-5.88; P = .013) and Olive Tail Moment (-2.93; P < .01).

Yoga may be an effective intervention for reducing DNA damage in individuals with type 2 diabetes.

Ultra-processed foods (UPFs) may be associated with obesity and asthma.

Reducing UPF consumption may benefit individuals at risk for obesity and asthma.

Recently completed and ongoing trials of dipeptidyl peptidase-4 inhibitors and sodium-glucose cotransporter 2 inhibitors will inform clinical practice on safe and effective ways to reduce cardiovascular risk in T2DM.

Healthcare providers should stay updated on findings from these trials to optimize T2DM treatment strategies.

Whole grain consumption reduced oxidative stress compared to refined grain consumption.

Practitioners may consider whole grains beneficial for reducing oxidative stress.

Obesity and diabetes mellitus are major risk factors for the development and progression of chronic kidney disease (CKD).

Healthcare providers should prioritize screening for CKD in patients with obesity and diabetes.

IgG antibody concentrations decreased in 83% of the targeted foods in the treatment group.

Targeted elimination diets may effectively reduce IgG levels for specific foods.

Caloric restriction-induced transcriptional reprogramming in adipose tissue implicated pathways regulating mitochondrial bioenergetics, anti-inflammatory responses, and longevity.

Caloric restriction may promote metabolic health through specific molecular pathways.

Reduction of PLA2G7 may mediate the immunometabolic effects of caloric restriction and could potentially lower inflammation and extend health span.

Targeting PLA2G7 may be a strategy to reduce inflammation and improve health span.

Omega-3 PUFA-derived mediators play a role in controlling inflammation and tissue homeostasis.

These mediators could be targeted for therapeutic strategies in inflammatory conditions.