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Long-term maintenance of a reduced weight provides the greatest health benefit.

Practitioners should emphasize the importance of long-term weight maintenance for health benefits.

Training to failure is proposed as a necessary strategy to maximize muscle growth.

Practitioners may consider incorporating training to failure in hypertrophy training.

The Colorado on the Move intervention was effective in significantly increasing physical activity over a 14-wk period.

Increasing daily steps by 2000 could help prevent weight gain in the population.

Simply increasing physical activity in the population by 2000 steps/d could help in preventing the average yearly increase in body weight seen in the US population.

Encouraging an increase in daily steps can be a simple public health strategy.

Steps/d appears to be a good target for use in interventions to increase physical activity.

Interventions should consider step count as a measurable goal.

Semaglutide reduced body weight more in women than in men, with a mean difference of -9.6% in women and -7.2% in men.

Practitioners should note that women may experience greater weight loss with semaglutide treatment.

Late bedtime was associated with general obesity (AOR, 1.20; 95% CI, 1.12-1.29) and abdominal obesity (AOR, 1.20; 95% CI, 1.12-1.28).

Encouraging earlier bedtimes may help reduce obesity risk.

Short nocturnal sleep of less than 6 hours was associated with general obesity (e.g., <5 hours: AOR, 1.27; 95% CI, 1.13-1.43).

Limiting sleep duration to at least 6 hours may help mitigate obesity risk.

Weight, body mass index (BMI), fat, and fat-free mass significantly decreased at month 12 after caloric restriction (CR) vs control.

Caloric restriction can effectively reduce weight and body composition metrics in healthy individuals.

The 4-min and 20-min TTs are strongly associated with the 60-min mean power output (MPO), with adjusted R2 = .98.

Shorter TTs can be effectively used to predict longer cycling performance in trained cyclists.

Postexercise protein-leucine supplementation increases branched-chain amino acid (BCAA) levels in plasma by 2.6-fold and in urine by 2.8-fold.

Supplementing with protein-leucine post-exercise can significantly boost BCAA levels.

Postexercise protein-leucine supplementation lowers serum creatine kinase concentration by 21%-25%.

Using protein-leucine supplements may help reduce muscle damage post-exercise.

Increases in strength were significantly greater in the 3 sets group (G3S) versus the 1 set group (G1S) in both the chest press (+26.6% vs. +20.3%) and the knee extension (+23.9% vs. +16.2%).

Practitioners should recommend multiple sets for optimizing strength gains in older women.

Multiple set protocols are required to optimize strength gains in older women.

Practitioners should focus on multiple set training for enhancing strength in older female populations.

Resistance exercise can effectively stimulate muscle protein synthesis (MPS) in cachexia patients using lower loads.

Practitioners can recommend lower resistance loads for cachexia patients to stimulate muscle growth.

Protein ingestion enhances resistance exercise-induced rates of muscle protein synthesis (MPS).

Incorporating protein intake post-exercise is crucial for maximizing MPS.

Rapidly digested, leucine-rich protein sources may stimulate greater post-exercise rates of MPS than other protein sources.

Choosing leucine-rich protein sources can enhance muscle recovery and growth post-exercise.

Intentional weight loss of 10% can potentially decrease A1C% by 0.81 among patients with type 2 DM.

Clinicians can use this information to encourage patients with type 2 DM to achieve a 10% weight loss to improve A1C levels.

Weight loss of 6.5 kg, 12.2 kg, and 15.9 kg is required to reduce A1C% by 0.5, 1, and 1.5, respectively.

Clinicians can guide patients on specific weight loss targets to achieve desired A1C reductions.

Patients achieved significant mean weight loss of 10.7 kg at study exit.

Clinicians can expect significant weight loss outcomes from structured weight management programs.

Lifestyle modification is recommended as the foundation for diabetes therapies.

Practitioners should prioritize lifestyle changes in diabetes management.

Lifestyle modifications can lead to reduced levels of glucose, blood pressure, and some lipids.

Implementing lifestyle changes can improve key health metrics in diabetic patients.

Dapagliflozin treatment is associated with weight reduction and a low propensity to cause hypoglycemia.

Dapagliflozin may help patients lose weight while minimizing the risk of low blood sugar.

Both constant load and ascending pyramidal load resistance training improve phase angle in older women after eight weeks.

Practitioners can use either training method to enhance phase angle in older female clients.