Browse the evidence

High sugar intake is associated with greater CHD risk, with a hazard ratio (HR) of 1.09 per 50 g/day.

Reducing sugar intake may help lower the risk of coronary heart disease.

For trials with mean baseline BMI <25, LDL cholesterol increased by 41 mg/dL on a low-carbohydrate diet.

Practitioners should be aware that low-carbohydrate diets may significantly raise LDL cholesterol in individuals with low BMI.

GLP-1 RA use was associated with lower medication use (RR, 0.53; 95% CI, 0.46-0.61; P < .001).

GLP-1 RAs may reduce the need for other medications in IIH management.

GLP-1 RA therapy is associated with significant reductions in procedural interventions (RR, 0.44; 95% CI, 0.30-0.63; P < .001).

GLP-1 RAs may reduce the need for surgical or other procedural interventions in IIH management.

High total carbohydrate intake is associated with high CVD morbidity (RR 1.08, 95% CI 1.02-1.13).

Limiting carbohydrate intake may help reduce the risk of cardiovascular disease.

High total fat intake is associated with a decreased all-cause mortality risk (RR 0.92, 95% CI 0.85-0.99).

Incorporating healthy fats into the diet may lower the risk of all-cause mortality.

Bariatric surgery is currently the most effective long-term treatment for morbid obesity and type-2 diabetes mellitus.

Practitioners should consider bariatric surgery as a primary treatment option for patients with morbid obesity and type-2 diabetes.

Moderate increases in physical activity following weight loss may elevate energy flux and improve appetite regulation.

Encouraging moderate physical activity can help clients manage their appetite and maintain weight loss.

>10% weight loss is associated with cardiovascular mortality (HR, 2.76; 95% CI, 1.87-4.09) in patients with type 2 diabetes.

>10% weight loss in patients with type 2 diabetes may indicate a higher risk of cardiovascular mortality.

Unintentional weight loss in patients with type 2 diabetes may be a warning sign of poor health.

Practitioners should investigate unintentional weight loss in patients with type 2 diabetes for potential health issues.

Changes in HbA1c were related significantly to changes in weight, but not to changes in REM-AHI and NREM-AHI.

Weight management is crucial for improving glycaemic control in this population.

Chronic nutritional carbohydrate overload has disruptive metabolic effects and detrimental health consequences.

Reducing carbohydrate intake may improve metabolic health.

Intermittent fasting, caloric restriction, exercise, and ketogenic diet have positive metabolic effects through modulation of redox homeostasis.

Incorporating these practices may enhance metabolic health and longevity.

Fatty acid metabolism is a key pathway modified by weight loss that predicts body weight maintenance 18 months after intended weight loss.

Practitioners should consider the role of fatty acid metabolism in developing weight maintenance strategies.

Variability of key enzymes in fatty acid metabolism and specific serum acylcarnitine species predict body weight maintenance.

Monitoring enzyme variability and acylcarnitine levels may help identify individuals at risk of weight regain.

Adaptation of lipid utilization in response to negative energy balance contributes to subsequent weight maintenance.

Understanding lipid utilization can inform strategies for effective weight maintenance post-weight loss.

Tai Chi exercise therapy significantly decreases triglyceride (TG) levels by an average of 0.23 mmol/L and increases high-density lipoprotein cholesterol (HDL-C) levels by an average of 0.15 mmol/L in patients with T2DM.

Tai Chi can be recommended to improve lipid profiles in T2DM patients.

Egg consumption is associated with a 38% lower risk of excessive body fat in females.

Promoting egg consumption in females may aid in managing body fat levels.

There are significant dose-response relationships between egg consumption and overweight with excessive body fat/central obesity in females.

Increasing egg intake may be beneficial for reducing body fat and obesity risk in females.

Treatment with SAR425899 resulted in a smaller reduction in body composition-adjusted sleeping metabolic rate (SMR) compared to placebo (p = 0.002).

SAR425899 may help mitigate metabolic adaptation during weight loss.

Fat oxidation and ketogenesis increased in both groups, with significantly greater increases in the SAR425899 group (p < 0.05).

SAR425899 may enhance fat metabolism, which could support weight loss efforts.

Both groups experienced an improvement in cardiometabolic risk markers after 12 months.

Improvements in cardiometabolic health may accompany weight loss in postmenopausal women.

Menopause leads to significant metabolic alterations and central and visceral fat redistribution in women.

Practitioners should be aware of the metabolic changes that occur during menopause and consider them in treatment strategies.

Changes in body composition at menopause influence risks of various health issues including cardiovascular disease and mental health disorders.

Health professionals should monitor and address the increased health risks associated with body composition changes during menopause.