Browse the evidence

Amylin promotes satiation and recruits multiple central nervous system pathways to regulate food intake.

Understanding amylin's role can help in developing obesity treatments.

Small-molecule GLP1RAs regulate both homeostatic and hedonic feeding through parallel neural circuits.

Practitioners can consider the dual impact of small-molecule GLP1RAs on different feeding behaviors.

GLP1RAs suppress the consumption of palatable foods by reducing dopamine release in the nucleus accumbens.

Understanding this mechanism can help in developing strategies to manage palatable food consumption.

Targeted deletion of the receptor in central amygdalar neurons diminishes the anorectic efficacy of GLP1RAs for reward-driven intake.

This finding highlights the importance of specific neural receptors in the effectiveness of weight loss drugs.

Intestinally derived messengers, including gut hormones and microbial metabolites, regulate feeding behavior.

Understanding these signals can help in developing targeted obesity treatments.

GLP-1 receptor agonism may decrease substance use and relapse.

GLP-1 receptor agonists may be beneficial in addiction treatment.

The hamstrings, iliopsoas, adductors, and tibialis anterior produced the largest downward acceleration about the center of mass.

Understanding these muscle contributions can help in designing rehabilitation programs focusing on these muscle groups.

Tirzepatide dose-dependently reduced voluntary alcohol consumption and prevented binge and relapse-like drinking.

Tirzepatide may help in managing alcohol use disorder by reducing consumption and preventing relapse.

The HIFEM+RF procedure is reported to be safe and effective, with high patient satisfaction and comfort.

Practitioners can expect high patient satisfaction and comfort with the HIFEM+RF procedure.

RIR rating accuracy did not significantly improve over time.

Practitioners should not expect RIR rating accuracy to improve significantly with time alone.

Food-related information is distributed across functionally distinct brain networks which act as opponent processes involved in guiding food-related behavior.

Understanding the distinct brain networks involved in food-related behavior can inform strategies for dietary interventions.

The inferred healthfulness or artificiality of foods is the greatest factor underlying similarity judgments, most strongly represented within the Prefrontal network.

Recognizing the impact of perceived healthfulness on food choices can aid in dietary planning.

The response to food images in the Prefrontal network is modulated strongly by judgments of the self-control required to resist eating those foods.

Understanding how self-control influences neural responses can help in developing strategies for better dietary choices.

Environmental cues such as chronic cold exposure, exercise, and caloric restriction potentiate adipocyte browning.

Incorporating cold exposure, exercise, and caloric restriction may enhance browning and its benefits.

GLP-1 receptor agonists can induce psychiatric side effects such as increased impulsivity, dysphoria, and aggression.

Physicians should be cautious of potential psychiatric side effects when prescribing GLP-1 RAs.

There may be a relationship between GLP-1 receptor agonists and mood.

Further investigation is warranted to understand the mood-related effects of GLP-1 RAs.

GLP-1 RAs influence blood pressure through mechanisms such as sympathetic nervous modulation, vasodilation, and diuretic effects.

Understanding these mechanisms can help in tailoring hypertension treatments.

Specific warm-up (SWU) protocols are similar to no warm-up (CON) regarding resistance training (RT) performance and perceptual responses.

Practitioners may consider skipping warm-up protocols to save time without compromising performance.

The comparison of 1SET and 2SET to CON indicated negligible to small potential differences for all outcomes.

The differences in warm-up protocols may not be significant enough to warrant changes in practice.

Posterior probabilities of SWU conditions being superior to CON remained relatively low for the bench press and 45° leg press.

There is little evidence to support the necessity of specific warm-up protocols for improving performance.

GLP-1 agonists may decrease sexual desire through increased serotonergic activity at the 5-HT2C receptor.

Clinicians should consider the potential impact of GLP-1 agonists on sexual desire when prescribing these medications.

The effects of GLP-1 agonists on sexual desire may be overlooked due to competing influences.

Awareness of these competing influences is crucial for healthcare providers managing patients on GLP-1 agonists.

GLP-1RAs provide direct neurovascular protection by stabilizing the blood-brain barrier and modulating neuroinflammation.

GLP-1RAs may be beneficial in protecting brain health and reducing stroke risk.

The findings suggest potential neurobehavioral benefits associated with incretin-based therapies (IBTs) in a high-risk population.

These findings may guide clinicians in selecting appropriate treatments for patients at risk of AUD post-surgery.