Browse the evidence

The significant effect of protein supplementation on muscle mass persisted across various subgroups, including age and gender.

Protein supplementation may be beneficial for muscle mass in diverse populations, regardless of age or gender.

Strength training can improve the quality of life of older adults with sarcopenia.

Practitioners should consider implementing strength training programs for older adults with sarcopenia to enhance their quality of life.

Strength training is more effective in high-intensity and supervised interventions.

Focus on high-intensity and supervised strength training for better outcomes.

Tirzepatide treatment resulted in a mean weight loss of 9.94 ± 4.8 kg and a percentage weight loss of 9.7 ± 4.8 % after 4 months.

Tirzepatide can be an effective option for weight management in patients with obesity.

Significant reductions were observed in body weight, BMI, waist circumference, absolute fat mass, body fat percentage, and visceral fat index.

Tirzepatide effectively reduces various measures of body fat in patients with obesity.

Whey protein supplementation had a significant effect on bench press performance (MD 5.72; 95% CI:1.30, 10.15; p=0.02).

Practitioners may consider recommending whey protein to enhance upper body strength in young adults involved in resistance training.

Sleep time increased by 36 ± 19 min from START to END (7h 36 ± 34 min vs 8h 12 ± 41 min) and sleep disturbances were not observed during the study period.

Practitioners can expect that sleep quality may be maintained or improved during competition preparation.

Protein supplementation has no negative effects on kidney performance in healthy adults who perform resistance training.

Practitioners can consider protein supplementation safe for kidney health in healthy adults engaged in resistance training.

Ingestion of whey protein during recovery from exercise increases myofibrillar protein synthesis rates.

Practitioners should consider whey protein as an effective supplement for enhancing muscle recovery post-exercise.

Protein ingestion increased circulating plasma amino acid concentrations.

Protein supplementation can effectively elevate amino acid levels in the bloodstream post-exercise.

Whey protein supplementation significantly improved bench press performance by a mean difference of 8.87 (95% CI: 5.95-11.79) and squat performance by a mean difference of 9.60 (95% CI: 5.61-13.60).

Practitioners can recommend whey protein to enhance strength performance in young adults engaged in resistance training.

Protein supplementation increased peak plasma total essential amino acids (EAA).

Practitioners can expect protein supplementation to enhance amino acid availability in young adults.

Regular strength training is highly effective for the prevention and treatment of sarcopenia.

Practitioners should implement regular strength training programs for older adults to prevent sarcopenia.

High-intensity training with 2 sessions of 30-45 minutes each is an efficient method for older adults.

Older adults should engage in high-intensity training sessions to maximize efficiency.

Supplementing strength training with adequate protein (≈1.6 g/kg) and creatine (≈3 g/d) enhances effects.

Practitioners should recommend protein and creatine supplementation alongside strength training for older adults.

Resistance training combined with dietary protein supplementation has synergistic benefits for older adults with sarcopenia or physical frailty, with a potential ceiling effect at 1.5-1.7 g PRO/kg BW/day.

Practitioners should recommend a combination of resistance training and protein supplementation within the specified range for older adults.

Whey-based multi-ingredient supplements are superior to isocaloric and isonitrogenous placebo for enhancing skeletal muscle growth in both younger and older persons.

Whey-based multi-ingredient supplements should be prioritized for muscle growth in diverse age groups.

Multi-ingredient formulations containing high-quality milk proteins, creatine monohydrate, vitamin D3, calcium, and n-3 polyunsaturated fatty acids may be recommended for the multimodal treatment of sarcopenia and sarcopenic obesity.

Practitioners should consider these multi-ingredient formulations in treatment plans for sarcopenia and sarcopenic obesity.

A lifestyle intervention increased weight loss at 8 years in overweight or obese patients with diabetes.

Implementing lifestyle interventions can be effective for weight loss in patients with diabetes.

Resistance exercise (RE) significantly increased metabolic flexibility in older men compared to no exercise (NE), with a medium-to-large effect size.

Incorporating resistance exercise into routines can enhance metabolic flexibility in older adults.

Higher frequency resistance training (RT) leads to significantly greater improvements in muscle strength compared to lower frequency RT.

Practitioners should consider increasing the frequency of resistance training sessions to enhance strength gains.

At 20 weeks, the protein group demonstrated greater improvement in the Short Physical Performance Battery and lower fat mass at 11 weeks.

Protein supplementation may lead to specific improvements in physical performance and fat loss in stroke patients.

A high-protein diet increased daily protein intake to 1.6 g/kg body weight and resulted in significantly increased concentrations of two metabolites and reduced concentrations of 98 metabolites compared to baseline.

Practitioners can consider a high-protein diet as a viable option for older adults to enhance metabolic health.

Protein and amino acid supplements are widely used by military personnel to increase muscle mass, enhance recovery, and support physical performance.

Practitioners should recognize the common use of protein supplements among military personnel for performance and recovery.