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Participants using the program plus medication were more likely to achieve clinically significant weight loss, with odds ratios ranging from 1.46 to 2.57 for ≥5% weight loss across timepoints.

Integrating a behavioral support app with GLP-1 RA treatment can significantly enhance weight loss outcomes.

Progress logging was associated with greater weight loss over time.

Encouraging users to log their progress can lead to better weight loss results.

Medication type was the strongest determinant of weight loss over time, with tirzepatide producing greater early reductions.

Choosing the right GLP-1 RA can significantly impact weight loss success.

Proper maintenance of skeletal muscle mass is essential to prevent sarcopenia and ensure health and quality of life as aging progresses.

Emphasizing muscle maintenance can improve health outcomes in aging populations.

The combination of resistance exercise and adequate protein intake is important for maintaining or increasing muscle mass.

Combining resistance training with adequate protein intake is crucial for muscle maintenance and growth.

Chronic ketone ester intake may blunt overreaching symptoms during short-term endurance training overload.

Practitioners may consider ketone esters to mitigate overreaching in endurance training.

Retatrutide yields a 24.2% reduction in total body weight at 48 weeks with 63% of participants achieving a total body weight loss of ≥20%.

Retatrutide may be an effective option for significant weight loss in patients.

Protein supplementation resulted in a significant positive effect on muscle mass with a weighted mean difference of 0.47 kg (95% CI, 0.18-0.75 kg; P < .001).

Practitioners should consider recommending protein supplementation to enhance muscle mass in healthy individuals.

Protein supplementation positively affected upper body strength.

Practitioners may recommend protein supplementation to improve upper body strength in healthy individuals.

The significant effect of protein supplementation on muscle mass persisted across various subgroups, including age and gender.

Protein supplementation may be beneficial for muscle mass in diverse populations, regardless of age or gender.

Strength training can improve the quality of life of older adults with sarcopenia.

Practitioners should consider implementing strength training programs for older adults with sarcopenia to enhance their quality of life.

Strength training is more effective in high-intensity and supervised interventions.

Focus on high-intensity and supervised strength training for better outcomes.

Tirzepatide treatment resulted in a mean weight loss of 9.94 ± 4.8 kg and a percentage weight loss of 9.7 ± 4.8 % after 4 months.

Tirzepatide can be an effective option for weight management in patients with obesity.

Significant reductions were observed in body weight, BMI, waist circumference, absolute fat mass, body fat percentage, and visceral fat index.

Tirzepatide effectively reduces various measures of body fat in patients with obesity.

Whey protein supplementation had a significant effect on bench press performance (MD 5.72; 95% CI:1.30, 10.15; p=0.02).

Practitioners may consider recommending whey protein to enhance upper body strength in young adults involved in resistance training.

Sleep time increased by 36 ± 19 min from START to END (7h 36 ± 34 min vs 8h 12 ± 41 min) and sleep disturbances were not observed during the study period.

Practitioners can expect that sleep quality may be maintained or improved during competition preparation.

Protein supplementation has no negative effects on kidney performance in healthy adults who perform resistance training.

Practitioners can consider protein supplementation safe for kidney health in healthy adults engaged in resistance training.

Ingestion of whey protein during recovery from exercise increases myofibrillar protein synthesis rates.

Practitioners should consider whey protein as an effective supplement for enhancing muscle recovery post-exercise.

Protein ingestion increased circulating plasma amino acid concentrations.

Protein supplementation can effectively elevate amino acid levels in the bloodstream post-exercise.

Whey protein supplementation significantly improved bench press performance by a mean difference of 8.87 (95% CI: 5.95-11.79) and squat performance by a mean difference of 9.60 (95% CI: 5.61-13.60).

Practitioners can recommend whey protein to enhance strength performance in young adults engaged in resistance training.

Protein supplementation increased peak plasma total essential amino acids (EAA).

Practitioners can expect protein supplementation to enhance amino acid availability in young adults.

Regular strength training is highly effective for the prevention and treatment of sarcopenia.

Practitioners should implement regular strength training programs for older adults to prevent sarcopenia.

High-intensity training with 2 sessions of 30-45 minutes each is an efficient method for older adults.

Older adults should engage in high-intensity training sessions to maximize efficiency.

Supplementing strength training with adequate protein (≈1.6 g/kg) and creatine (≈3 g/d) enhances effects.

Practitioners should recommend protein and creatine supplementation alongside strength training for older adults.