Browse the evidence

Alternate day fasting was the only form of intermittent fasting diet strategy to show benefit in body weight reduction compared with continuous energy restriction.

Alternate day fasting may be a more effective intermittent fasting strategy for weight loss compared to continuous energy restriction.

Oral semaglutide at a dose of 25 mg once daily resulted in a mean reduction in body weight of -13.6% from baseline to week 64.

Oral semaglutide may be an effective treatment option for weight loss in adults with obesity.

Participants in the oral semaglutide group were significantly more likely to achieve body-weight reductions of 5% or more, 10% or more, 15% or more, and 20% or more compared to the placebo group.

Oral semaglutide may help patients achieve significant weight loss milestones.

Limiting consumption of ultra-processed foods may be an effective strategy for obesity prevention and treatment.

Encouraging clients to limit ultra-processed food intake may support weight management efforts.

VLCD and COMB resulted in a 5.4 and 7 percentage-point greater weight loss than SEM, respectively.

Practitioners should consider VLCD or its combination with Semaglutide for greater weight loss in patients with T2D.

Semaglutide use is associated with a substantial decrease in long-term relative body weight of -12.1% compared to placebo.

Semaglutide can be considered an effective treatment option for weight loss in patients with obesity who do not have diabetes.

33.4% of participants randomized to semaglutide achieved ≥20% weight loss compared to 2.2% with placebo.

A significant proportion of patients may achieve substantial weight loss with semaglutide, making it a viable option for obesity management.

In Chinese adults with overweight or obesity, once-weekly mazdutide at a dose of 4 mg for 32 weeks led to a mean percentage change in body weight from baseline of -10.09%.

Mazdutide may be an effective treatment option for weight loss in adults with obesity or overweight.

In the 6-mg mazdutide group, the mean percentage change in body weight from baseline at week 32 was -12.55%.

Higher doses of mazdutide may lead to greater weight loss in adults with obesity or overweight.

73.9% of participants in the 4-mg mazdutide group achieved a weight reduction of at least 5% at week 32.

A significant proportion of adults with obesity or overweight may benefit from mazdutide treatment.

Tirzepatide (TZP) resulted in a mean body weight loss of 16.7 kg compared to 8.3 kg with placebo (PBO) after 18 weeks (p<0.001).

Tirzepatide may be an effective treatment for weight loss in individuals with obesity.

TZP significantly decreased food intake during lunch and dinner compared to PBO.

TZP may help reduce overall food consumption in individuals with obesity.

Weight management treatments (WMT) increased the probability of achieving 5% or greater weight loss.

Implementing WMT can significantly enhance weight loss outcomes for patients.

Increasing physical activity is associated with the lowest obesity odds compared to stable physical activity-diet.

Practitioners should encourage increased physical activity to reduce obesity risk.

Increasing physical activity with improved diet is associated with the largest reductions in body fat percentage, body mass index, and waist circumference.

Encouraging both increased physical activity and dietary improvements can maximize fat loss.

Time-restricted feeding (TRF) combined with a low-calorie diet resulted in significantly greater reductions in weight, BMI, waist circumference, and body fat mass compared to a low-calorie diet alone after 8 weeks.

Practitioners may consider recommending TRF combined with a low-calorie diet for better weight management in overweight and obese women with food addiction.

Both fasted and fed aerobic exercise groups showed a significant loss of weight (P = 0.0005) and fat mass (P = 0.02) from baseline.

Both fasted and fed aerobic exercise can be effective for fat loss when combined with a caloric deficit.

Body composition changes associated with aerobic exercise in conjunction with a hypocaloric diet are similar regardless of fasting status.

Practitioners can focus on caloric deficit rather than fasting status for body composition goals.

94.2% of patients achieved ≥ 5% weight loss after 6 months of tirzepatide treatment.

Practitioners can expect a high rate of significant weight loss among patients using tirzepatide.

Overall energy balance is the major determinant in weight management.

Practitioners should focus on managing energy balance for effective weight management.

Calories in versus calories out ultimately determines whether weight is gained, lost, or maintained.

Understanding energy balance is crucial for weight management.

HP diets, whether rich or restricted in red meat, are effective for decreasing body fat.

Practitioners can recommend HP diets, including lean beef, for weight loss.

Consuming lean beef as part of a HP diet does not negatively impact body fat loss compared to a diet restricted in red meats.

Lean beef can be included in HP diets without compromising fat loss.

Body fat percentage and fat mass significantly decreased during the 16-week intervention.

Weight loss interventions can lead to significant reductions in body fat and fat mass.